Author: Urenus

Drops _ Injection solution Composition:

Drops: 100 g cont.: Senecio nemorensis ssp. fuchsii D6, Acidum nitricum D4, Erigeron canadensis D3, Moschus moschiferus D6, Viburnum opulus D3, Pulsatilla pratensis D4, Sepia officinalis D6, Cyclamen europaeum D4, Ignatia D6, Thlaspi bursa pastoris D3 5 g each; Calcium carbonicum Hahnemanni D8, Aquilegia D4, Cypripedium calceolus var. pubescens D8, Origanum majorana D4, Nux moschata D6 10 g each. Contains 35 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Senecio nemorensis ssp. fuchsii D6, Acidum nitricum D4, Erigeron canadensis D3, Moschus moschiferus D6, Viburnum opulus D3, Pulsatilla pratensis D4, Sepia officinalis D6, Cyclamen europaeum D4, Ignatia D6, Thlaspi bursa

pastoris D3 0.55 µl each; Calcium carbonicum Hahnemanni D8, Aquilegia D4, Cypripedium calceolus var. pubescens D8, Origanum majorana D4, Nux moschata D6 µl each.

Indications:

Functional disturbance of the female cycle. For the auxiliary medicinal treatment of sterility. To regulate the function of the endocrine glands.

Dosage:

Drops: In general, 10 drops 3 times daily.

Injection solution: Initially daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d.,  i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Senecio nemorensis ssp. fuchsii (senecio)

Amenorrhoea, dysmenorrhoea, irregular menses with irritation of the bladder; after commencement of menses improvement of all disorders, haemostyptic action.

Acidum nitricum (nitric acid)

Ammoniacal fluor albus, incontinentia urinae, action on the mucous membranes, uterine haemorrhages, metrorrhagia.

Erigeron canadensis (fleabane)

Bright red haemorrhages with irritation of the bladder, menorrhagia, fluor albus.

Moschus moschiferus (glandular secretion of the male musk deer) Dysmenorrhoea, fainting and conditions of excitation.

Viburnum opulus (guelder rose) Dysmenorrhoea, abortus imminens. Pulsatilla pratensis (wind flower)

Amenorrhoea, migrating pains, fluor albus, constitutional remedy. Sepia officinalis (cuttlefish)

Hysteroptosis, downward pressure, chronic inflammation of the uterus and adnexa, acrid fluor albus, pruritus vulvae, exhaustion climacteric.

Cyclamen europaeum (cyclamen) Dysmenorrhoea, stabbing and irritating pains. Ignatia (St. Ignatius’ bean)

Irregular menses with spasmodic pains, lability of mood, tendency to weep, migraine. Thlaspi bursa pastoris (pennycress)

Metrorrhagia, menorrhagia, fluor albus, chronic cystitis, haemorrhages. Calcium carbonicum Hahnemanni (inner white part of the oyster shell)

Pre-menstrual headaches, colic, burning, irritation; displacement of uterus (tendency), uterine polypi, scrofulous glandular swelling.

Aquilegia vulgaris (columbine)

Dysmenorrhoea with pain on the left side, globus hystericus. Cypripedium calceolus var. pubescens (lady’s slipper) Nervous disorders in overstrained women, insomnia.

Origanum majorana (marjoram)

Nervous irritability, colic, galactagogue for nursing mothers with (painful) milk tumours. Nux moschata (nutmeg apple)

Abortus imminens, meteorism, nervous hyperactivity.

Hormeel S, due to its individual constituents, exerts a mildly stimulating action, in the combination effect (Bürgi), on the endocrine glands, especially on the hypophysis cerebri, through mobilization of the tropic hormones on the endocrine glands situated below (gonads, thyroid gland, suprarenal glands); further, also on the connective tissues, and it can, therefore, be applied as auxiliary remedy for the widest variety of indications in which there is a suspicion of hormonal dysfunction.

Based on the individual homoeopathic constituents of Hormeel S, therapeutical possibilities result for the treatment of functional disturbances in the female cycle, symptoms of ovarian and hypophyseal insufficiency, amenorrhoea, dysmenorrhoea (in the latter case, Spascupreel and Gynäcoheel in addition); as auxiliary medicinal treatment of sterility and in habitual miscarriage. Neurovegetative and psychosomatic disturbances (migraine, depression, nymphomania, in these cases possibly alternating with Ypsiloheel and Nervoheel). Female sterility (in combination with Gynäcoheel and Apis_Homaccord); climacteric (in addition to Klimakt-Heel and Metro-Adnex-Injeel).

As auxiliary remedy, Hormeel S is administered in oophoritis, adnexitis, salpingitis, para-, myo-, endometritis and colpitis (with Metro-Adnex-Injeel, Traumeel S and Gynäcoheel), in fluor albus (with Gynäcoheel and Lamioflur), in Kraurosis vulvae (with Mercurius-Heel S, Mezereum-Homaccord, possibly also Schwef-Heel, Sulfur-Injeel S, Klimakt-Heel, etc.).

Additional indications for Hormeel S are gynecological cystitis, various skin diseases such as neurodermatitis, rosacea, acne vulgaris juvenilis, as well as diseases of the mucous membranes (rhinitis, pharyngitis, laryngitis, laryngeal weakness (in addition to Phosphor-Homaccord and ), aphthous stomatitis, aphthe, struma parenchymatosa, hyperthyroidism) and loss of appetite in childhood (in addition to Lymphomyosot, Hepeel and Calcoheel). The dosage is adapted according to the disease, the clinical picture and the stage of the illness: In continuous treatment 10 drops 3-4 times daily. As massive initial-dose therapy to stimulate the hormones, 5-10 drops hourly, in addition 1 ampoule i.m., s.c., i.v., i.d., possibly with auxiliary remedies, at first daily, then later 1-3 times weekly. Hormeel S can cause the menses to begin prematurely, thereby, in our opinion, provoking increased haemorrhages.

Compositions

Tablets
1 tablet containing: Lycopodium clavatum D3, Chelidonium majus D6, Cinchona pubescens D3, Myristica fragrans D4 30 mg each; Silybum marianum D2, Phosphorus D6 15 mg each; Veratrum album D6 60 mg; Citrullus colocynthis D6 90 mg.

Injection solution
1.1 ml containing: Lycopodium clavatum D2, Chelidonium majus D6, China D2, Myristica fragrans D3 1.1 mg each; Silybum marianum D1, Phosphorus D5 0.55 mg each; Veratrum album D5 2.2 mg; Citrullus colocynthis D5 3.3 mg.

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Indications

Primary and secondary functional disorders of the liver; damaged liver.

Contraindications

Because of the constituent Celandine (Chelidonium) do not use during pregnancy and lactation. Do not use in case of hypersensitivity to Carduus marianus or other plants of the daisy family (Asteraceae) or in case of hypersensitivity to quinine.

Side effects

In rare cases, reactions of hypersensitivity, such as skin allergy or fever, may occur after exposure to drugs that contain quinine. In such cases, you must see a doctor.

Note

A quinine or quinidine sensitization may occur.

Interactions with other medication

None known.

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Dosage

Tablets
Standard dosage: Adults (and children 12 yrs and older): 1 tablet to be dissolved in the mouth 3× daily.

Injection solution
Standard dosage: Adults (and children 12 yrs and older): 1 ampoule 1 to 3× weekly. Hepeel injection solution may be administered by the s.c., i.d., i.m. or i.v. route.
Acute or initial dosage: Adults (and children 12 yrs and older): 1 ampoule daily, and then continue with standard dosage.

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Package sizes

Tablets: Packs containing 50 and 250 tablets. (47787)
Injection solution: Packs containing 10 and 100 ampoules of 1.1 ml each. (46791)

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Pharmacological notes

• Lycopodium clavatum: liver cirrhosis,1-8 cholecystitis,9 hepatitis,2-6,10-15 dermatoses,1,10,12,14,16-19 dermatitis,6,20 jaundice,2,14,19,21-25 abdominal distention,5,22,25-27 gastritis,1,5,6,14,21,25-28 eczema,1,10,12,14,16,17,19,23,25,28,29 and acne,6,7,10,19,25,27
• Chelidonium majus: liver cirrhosis,5,14,27,30,31 jaundice,1,10-12,15-22 abdominal distention,14,17,27,31 and gastritis,5,21,27,28
• Cinchona pubescens: gastritis,5-6,9,13,25 loss of appetite,4,11,12,14,16,25,28,31,37,38 liver cirrhosis,5-7,30-31 hepatitis,5,13,25,27,30,33 and cholecystitis,5,23
• Myristica fragrans: liver cirrhosis and loss of appetite,4-7,11,12,14,16,21,25,27,33,34,40,41
• Silybum marianum: liver cirrhosis,4-6,15-17,21,26,34 hepatitis,5-7,32,37 cholecystitis,6 and loss of appetite,4,6,9,16,26,30
• Phosphorus: liver cirrhosis,2-7,10-14,19,26,27,38,42 gastritis,5,11-14,18,22,36,43 hepatitis,4,10,12-14,19,25,26,40,44 and abdominal distention,7,16,18,22,25,27
• Veratrum album: abdominal distention,6,14-16,25-28,45,46 liver cirrhosis, hepatitis, loss of appetite,1,5,7,14,16,25,46 acne,6,7,14,27,30 and eczema
• Citrullus colocynthis: abdominal distention,6,7,14,16,25,38,41,46-48 loss of appetite,5,14,16,25,27 and jaundice,8,20

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Clinical notes

Because of the individual constituents of Hepeel, the medication can be offered for the following conditions:

1. Liver disorders: liver cirrhosis, hepatitis, and jaundice.
2. Other intestinal disorders: gastritis, abdominal bloating, gastrocardiac syndrome, cholangitis, and cholecystitis.
3. Loss of appetite.
4. Adjunctive therapy in chronic diseases, such as dermatoses, eczema, and acne vulgaris.

Note: Hepeel was recently examined for its in vitro effect on HepG2 hepatoblastoma cells. It has significant antioxidative, antiproliferative, and biochemical effects that point toward a hepatoprotective and tumerostatic action. Hepeel can be used in disorders such as cirrhosis, which has a potentially malignant outcome; the previously described evidence suggests the mechanism of its protective action.

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References

1. Gebhardt R. Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Arzneimittel-Forschung. 2003;53(12):823-830.
2. Alen TE. Handbook of Materia Medica and Homeopathic Therapeutics. 1st ed. New Delhi, India: Jain Publishers Ltd; 1889.
3. Farrington H. Homeopathy and Homœopathic Prescribing (Prepared for and Offered Only to Graduate Physicians). 1st ed. Philadelphia, PA: American Institute of Homœopathy; 1965.
4. Farrington EA. A Clinical Materia Medica Being a Course of Lectures Delivered at the Hahnemann Medical College of Philadelphia. 2nd ed. Philadelphia, PA: Hahnemann Publishing House; 1890.
5. Lilienthal SN. Homœopathic Therapeutics. 5th ed. Calcutta, India: S. Dey & Co.; 1925.
6. Monisan R. Desk Manual Companion to Physical Pathology. 1st ed. Albany, CA: Hahnemann Clinic Publishing; 1998.
7. Murphy R. Homeopathic Medical Repertory: A Modern Alphabetical Repertory. 1st ed. Pagosa Springs, CO: Hahnemann Academy of North America; 1993.
8. Schrayens F. Synthesis: Repertorium Homœopathicum Syntheticum. 5th ed. London, England: Homœopathic Book Publisher; 2004.
9. Royal G. Textbook of Homœopathic Materia Medica. 1st ed. Calcutta, India: Ray Publishing House; 1920.
10. Gupta RL. Directory of Diseases and Cures in Homœopathy: 1500 Authoritative References with Causes & Symptoms. Vol. 1-2. 1st ed. New Delhi, India: Jain Publishers Ltd; 1989.
11. Boericke W. Boericke’s Manual of Homœopathic Materia Medica with Repertory Comprising the Characteristics and Guiding Symptoms of All Remedies. 9th ed. Santa Rosa, CA: Boericke & Tafel; 1927.
12. Buck L. The Outlines of Materia Medica and a Clinical Dictionary. 1st ed. New Delhi, India: Jain Publishers Ltd; 1865.
13. Surt WH. Physiological Materia Medica. 5th ed. Chicago, IL: Gress & DeBridge; 1896.
14. Cleveland CL. Salient Materia Medica and Therapeutics. 1st ed. New Delhi, India: Jain Publishers Ltd; 1888.
15. Hering C. The Guiding Symptoms of our Materia Medica. Vol. 1-10. 1st ed. New Delhi, India: Jain Publishers Ltd; 1989.
16. Allen TF. The Encyclopedia of Pure Materia Medica: A Record of the Positive Effects of Drugs upon the Healthy Human Organism. Vol. 1-12. 1st ed. Phatak SR: Materia Medica of Homœopathic Medicines. 1st ed. London, England: Foulset & Vaughan Publishing; 1988.
17. Clarke JH. Clinical Lectures on Materia Medica. 3rd ed. London, England: Boericke & Tafel; 1899.
18. Dunham C. Lectures on Materia Medica. 3rd ed. Philadelphia, PA: Boericke & Tafel; 1934.
19. Hesoun P. The Homœopathic Treatment of Children: Pediatric Constitutional Types. 1st ed. Berkeley, CA: North Atlantic Books; 1991.
20. Vermeulen F. Prima – The Arcana of Materia Medica Illustrated. 2nd ed. The Netherlands: Emryss Publishers; 2002.
21. Blackwood AL. A Manual of Materia Medica, Therapeutics and Pharmacology (with Clinical Index). 2nd ed. New Delhi, India: World Homœopathic League; 1922.
22. Borland DM. Digestive Drugs. New Delhi, India: Jain Publishers Ltd; 1994.
23. Degrost E. Physical Examination and Observations in Homœopathy. 1st ed. Gent, Belgium: Homœopathic Book Service; 1992.
24. Farrington EA. Lesser Writings with Therapeutic Hints. 1st ed. Calcutta, India: Salzer & Co.; 1935.
25. Hoyne TS. Clinical Therapeutics. Vol. 1-2. New Delhi, India: Jain Publishers Ltd; 1979.
26. Hughes R. Cyclopaedia of Drug Pathogenesy. Vol. 1-4. 1st ed. New Delhi, India: World Homœopathic Link; 1891.
27. Vermeulen F. Concordant Materia Medica. 2nd ed. The Netherlands: Merija Publishers; 1997.
28. Kent JT. Lectures on Homœopathic Materia Medica. 10th ed. London, England; New York, NY; Philadelphia, PA: Boericke & Tafel; 1946.
29. Allen IF. A Primer of Materia Medica for Practitioners of Homœopathy. 1st ed. Philadelphia, PA: Boericke & Tafel; 1892.
30. Clarke JH. A Dictionary of Practical Materia Medica. Vol. 1-3. 3rd ed. Bradford, England: Health Science Press; 1977.
31. Hale EM. Special Symptomatology of the More Remedies. New Delhi, India: Jain Publishers Ltd.
32. Allen HC. Keynotes and Characteristics with Comparisons of Some of the Leading Remedies of the Materia Medica. 2nd ed. Wellingborough, England; Gregg Press Inc.; 1964.
33. Boger CMLA. Synoptic Key of the Materia Medica. 10th ed. New Delhi, India: Jain Publishers Ltd; 1931.
34. Rastogi D. Homœopathic Gems. 2nd ed. New Delhi, India: Jain Publishers Ltd; 1997.
35. Ales HC. The Therapeutics of Intermittent Fever. 2nd ed. New Delhi, India: Jain Publishers Ltd; 1884.
36. Choudhuri NM. A Study on Materia Medica and Repertory. New Delhi, India: Jain Publishers Ltd; 1929.
37. Murphy R. The Homœopathic Remedy Guide: 1200 Homœopathic and Herbal Remedies. 1st ed. Blacksburg, VA: HANA Press; 2000.
38. Lippe AJ. Keynotes and Red Line Symptoms of Materia Medica. New Delhi, India: Jain Publishers Ltd; 1998.
39. Mohanty N. Textbook of Homœopathic Materia Medica. 1st ed. New Delhi, India: Jain Publishers Ltd; 1997.
40. Farrington EA. Comparative Materia Medica. 3rd ed. New Delhi, India: Jain Publishers Ltd; 1983.
41. Leeser O. Textbook of Homœopathic Materia Medica: Inorganic Medicinal Substances. 1st ed. New Delhi, India: Jain Publishers Ltd; 1980.
42. Dewey WA. Practical Homeopathic Therapeutics. 3rd ed. Philadelphia, PA: Boericke & Tafel; 1934.
43. Hahnemann S. Materia Medica Pura. Vol. 1-2. 1st ed. London, England: Homœopathic Book Publishers; 1880.
44. Gibson DM. Studies of Homeopathic Remedies. 1st ed. Beaconsfield, England: Beaconsfield Publishers Ltd; 1987.
45. Dewey WA. Practical Homeopathic Therapeutics. 3rd ed. Philadelphia: Boericke & Tafel; 1934.
46. Hahnemann S. Materia Medica Pura. Vol 1–2. 1st ed. London: Homœopathic Book Publishers; 1880.
47. Gibson DM. Studies of Homeopathic Remedies. 1st ed. Beaconsfield: Beaconsfield Publishers; 1987.
48. Hahnemann S. The Chronic Diseases, Their Peculiar Nature and Their Homeopathic Cure. Vol 1–2. 2nd ed. New Delhi: Jain Publishers; 1981.
49. Gebhardt R. Antioxidative, antiproliferative and biochemical effects in HepG2 cells… Arzneimittel-Forschung. 2003;53(12):823-830.

Injection solution Composition:

Injection solution: 2.2 ml cont.: Hepar suis D8, Cyanocobalaminum D4, Duodenum  suis D10, Thymus suis D10, Colon suis D10, Vesica fellea suis D10, Pankreas suis D10, China D4, Lycopodium clavatum D4, Chelidonium majus D4, Carduus marianus D3, Histaminum D10, Sulfur D13, Avena sativa D6, Fel tauri D8, Natrium diethyloxalaceticum D10, Acidum alpha-ketoglutaricum D10, Acidum DL-malicum D10, Acidum fumaricum D10, Acidum alpha-liponicum D8, Acidum oroticum D6, Cholesterinum D10, Calcium carbonicum Hahnemanni D28, Taraxacum officinale D4, Cynara scolymus D6, Veratrum album D4 22 µl each.

Indications:

Stimulation of the detoxicating function of the liver in acute and chronic diseases of the liver/gall, e.g. cholangitis and cholecystitis; in functional disorders of the liver of toxic origin as cause or result of other diseases, in hypercholesteremia, erythematodes,  toxic exanthema, dermatosis and dermatitis, neurodermitis and for the stimulation of the liver cell functioning.

Dosage:

In general, 1 ampoule i.m., s.c., i.d., or, if necessary, i.v., 3-1 times weekly.

Package sizes:

Packs containing 5, 10, 50 and 100 ampoules of 2.2 ml.

Pharmacological and clinical notes

Cyanocobalaminum (Vitamin B12)

Damage to the liver parenchyma, disturbance of the detoxicating hepatic function, disturbance of the fat and carbohydrate metabolism.

Hepar suis (liver)

Stimulation of the detoxicating hepatic function. Duodenum suis (duodenum)

Duodenitis, duodenal ulcers, gastrocardiac syndrome. Thymus suis (thymus gland)

Stimulation of the lymphatic system, neoplasm phases, disturbances to growth and development.

Colon suis (large intestine)

Stimulates the detoxicating and secretory processes, intestinal stasis, intestinal tenesmus, colitis mucosa et ulcerosa.

Vesica fellea suis (gall bladder) Chronic cholangitis and cholecystitis. Pankreas suis (pancreas)

Pancreopathy, chronic enteritis, marasmus, cachexia. China (Peruvian bark)

Remedy for debility, flatulent colic, biliary colic, enlargement of liver, gastroduodenitis. Lycopodium clavatum (club-moss)

Diseases of the hepatic and cystic ducts, loss of appetite or Iycorexia, meteorism, pale yellowish complexion.

Chelidonium majus (celandine)

Cholelithiasis, cholecystitis, cholangitis, biliary colic, pain under the right shoulder blade, hepatopathy.

Carduus marianus (milk thistle)

Liver damage, congestion of the portal vein, biliary colic, haemorrhoids. Histaminum (histamine)

To support the detoxicating function, increased glandular secretion, eczema and dermatosis.

Sulfur (sulphur)

Reagent in all chronic diseases; cellular activity is influenced catalytically. Avena sativa (common oats)

Nervous exhaustion; recommended for manias. Fel tauri (ox bile)

Diseases of the liver and gall bladder, cholelithiasis. Natrium diethyloxalaceticum (sodium oxalacetate)

Active factor of the citric acid cycle and of redox systems; intolerance to fats and albumin.

Acidum alpha-ketoglutaricum (a-ketoglutaric acid)

Active factor of the citric acid cycle and of redox systems; feeling of weakness. Acidum DL-malicum (malic acid)

Active factor of the citric acid cycle and of redox systems; promotes detoxication. Acidum fumaricum (fumaric acid)

Active factor of the citric acid cycle and of redox systems; conditions of exhaustion. Acidum alpha-liponicum (thioctic acid)

Coenzyme in the decomposition of pyruvic acid. Orotic acid (lactic acid)

Liver damage. Cholesterinum (cholesterol)

Cholelithiasis, cirrhosis of the liver, cancer of the liver.

Calcium carbonicum Hahnemanni (inner white part of the oyster shell)

Conditions of exhaustion, pain in the epigastrium upon contact, persistent flatulence, biliary colic.

Taraxacum officinale (dandelion)

Cholecystopathy, hepatopathy with and without jaundice, meteorism, flatulence, congestion of the portal vein, gastritis.

Cynara scolymus (globe artichoke)

Stimulation of the detoxicating hepatic function and of diuresis; tonic. Veratrum album (white hellebore)

Affections starting feverishly, chronic vomiting, diarrhoea, conditions of collapse.  Based    on the individual  homoeopathic constituents of Hepar compositum, therapeutical possibilities result for the stimulation of the detoxicating hepatic function

in acute and chronic effectations of the liver and gall bladder, e.g. for cholangitis, cholecystitis; also, however, of disturbances of the hepatic function of toxic origin: cirrhosis of the liver, hepatitis epidemica, as well as disturbances of the hepatic function as the cause or consequence of other diseases; for hypercholesterinaemia, erythematosus, toxic exanthema, dermatosis and dermatitis, neurodermatitis, and to stimulate the functions of the liver cells.

The active substances combined in Hepar compositum, such as Vitamin B12, organ extracts and homoeopathic medicaments particularly aimed at the hepatic functions, complement themselves synergistically with potentiated action.

The action of Hepar compositum can be increased by the intermediate administration of Ubichinon compositum ampoules, Coenzyme compositum ampoules and possibly Thyreoidea compositum (antineoplastic action).

If the disorders are located more in the left side of the epigastrium or alternate from side to side, intermediate injections of Momordica compositum, Ceanothus- Homaccord, possibly also Leptandra compositum, and if there is a suspicion of neoplasia, also Podophyllum compositum as well as Viscum compositum (medium, forte), etc. are indicated.

Alternating injections with Hepeel, Injeel-Chol and possibly Chelidonium-Homaccord exert a favourable action; for suitable symptoms, possibly also with Nux vomica- Homaccord. The latter preparations should also be administered, according to the symptoms in each case, orally with Chelidonium-Homaccord.

Alternating remedies for intestinal stasis are Leptandra compositum, Momordica compositum, Nux vomica-Homaccord and Papaver-Injeel forte, and possibly also Dioscorea-Injeel forte.

The dosage is adjusted according to the disease, the clinical picture and the stage of the illness: initially 1 ampoule s.c., i.m., possibly i.v. 3 times weekly; in the further course of treatment 1 ampoule s.c. only once to twice weekly, alternating with auxiliary remedies.

Ointment Composition:

100 g cont.: Hamamelis virginiana Ø 10.0 g. Ointment base: hydrophilic ointment (DAB 10) cont.: emulsifying cetylstearyl alcohol, ethanol, purified water, liquid paraffin, soft white paraffin, preserved with 14.5 Vol.-% ethanol.

Indications:

Varicosis, haemorrhage of the skin and the mucosa.

Contraindications:

Hypersensitivity to constituents of the ointment base.

Side effects:

None known.

Interactions with other medication:

None known.

Method of application:

In general, spread over the affected parts of the skin once to twice daily. Package sizes:

Tube containing 50 g of ointment.

Pharmacological and clinical notes

Hamamelis virginiana (witch-hazel)

Venous stasis, varicose veins, (thrombo-)phlebitis, crural ulcers, haemorrhoids, venous haemorrhages.

Drops _ Injection solution Composition:

Drops: 100 g cont.: Hamamelis virginiana D2, Hamamelis virginiana D30, Hamamelis virginiana D200 0.8g each; Carduus marianus D6, Carduus marianus D30, Carduus marianus D200 0.2 g each. Contains 35 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Hamamelis virginiana D4, Hamamelis virginiana D30, Hamamelis virginiana D200 8.8 µl each; Carduus marianus D6, Carduus marianus D30, Carduus marianus D200 2.2 µl each.

Indications:

Venous stasis, varicose eczema, thrombophlebitic conditions.

Dosage:

Drops: In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, over a period lasting up to two hours. Long-term application of the  preparation (over several months or longer) must be supervised by a therapist.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Hamamelis virginiana (witch-hazel)

Venous stasis, varicose veins, (thrombo-)phlebitis, crural ulcers, haemorrhoids, venous haemorrhages.

Carduus marianus (milk thistle)

Remedy for disorders of the hepatic functions, varicose syndrome.

Based on the individual homoeopathic constituents of Hamamelis-Homaccord, therapeutic possibilities result for the treatment of venous stasis, varicose syndrome, crural ulcers, sural spasms (in addition to Spascupreel and Veratrum-Homaccord), sensation of heaviness in the legs, intermittent claudication (in addition to Arteria-Heel and Circulo-Injeel), phlebitis, thrombophlebitis (in addition to Belladonna-Homaccord and possibly Traumeel S, Cruroheel S), oedema of the legs (with Apis_Homaccord).

Erythema exsudativum multiforme et nodosum (in addition to Abropernol, Cruroheel S, Traumeel S tablets and possibly Osteoheel S); is often needed in addition to Cinnamomum-Homaccord N for haemorrhages. It has an absorbing action in cases of haematomas, ecchymosis, haemarthrosis (in addition to Traumeel S) orally and intradermal Iocally. The dosage is adjusted according to the disease, the symptoms and the stage of the illness: 10 drops 3-4 times daily. In conditions of pain (leg) or thrombophlebitis, firstly an aggregate dosage of 10 drops every 15-30 minutes. 1 ampoule 1-3 times weekly; for thrombophlebitis (with Belladonna-Homaccord, etc.) initially 1 ampoule daily i.m., s.c., i.d., i.v., otherwise 1-3 times weekly.

Drops Composition:

100 g cont.: Apis mellifica D4, Ammonium bromatum D4, Lilium tigrinum D4, Aurum jodatum D12, Crabro vespa D4, Helonias dioica D4, Palladium metallicum D12, Platinum metallicum D12, Naja naja D12 10 g each; Melilotus officinalis D3, Viburnum opulus D2 5 g each. Contains 35 vol.-% alcohol.

Indications:

Inflammatory conditions of the female genital organs, e.g. adnexitis (ovaritis, salpingitis), parametritis, myometritis, endometritis, colpitis.

Contraindications:

The preparation includes an iodine-containing ingredient. In cases of thyroid disorder with reduced iodine tolerance use only on the advice of a physician.

Side effects:

None known.

Interactions with other medication:

None known.

Dosage:

In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, over a period lasting up to two hours.

Package sizes:

Drop bottles containing 30 and 100 ml.

Pharmacological and clinical notes

Apis mellifica (honey bee)

Oedema: ovaritis, right; hypersensitivity, nervousness. Ammonium bromatum (ammonium bromide)

Calming action, neuralgic headaches. Lilium tigrinum (tiger lily)

Fluor albus, dysmenorrhoea, uterus descensus, nervous cardiac disturbances, colpitis. Aurum jodatum (gold iodide)

Myomas, ovarial cysts, arteriosclerosis. Crabro vespa (hornet)

Ovaritis, left.

Helonias dioica (stud flower)

Conditions of exhaustion, uterus descensus et prolapsus, endometritis, remedy for women’s ailments.

Palladium metallicum (palladium) Ovaritis, ovarial cysts.

Platinum metallicum (platinum)

Increasing    and    decreasing    pains, mental changes, menorrhagia, myomatous haemorrhages, pruritus vulvae.

Naja naja (spectacled snake)

For affections of the ovaries, pain extending to the heart. Melilotus officinalis (melilot)

Venous remedy, dysmenorrhoea, ovaralgia. Viburnum opulus (guelder rose) Dysmenorrhoea.

Based on the individual homoeopathic constituents of Gynäcoheel, therapeutic possibilities result for the treatment of inflammatory processes (reaction phases) and functional diseases of the female germinal tissue (germinoderm); ovaritis, salpingitis, para-, myo-, endometritis, colpitis, possibly in combination with Metro-Adnex-Injeel, Hormeel S and Traumeel S, possibly Arnica-Heel and Apis_Homaccord; fluor albus (combination with Lamioflur, Hormeel S and Traumeel S, possibly Klimakt-Heel); kraurosis vulvae (in combination with Mercurius-Heel S, Hormeel S, Mezereum- Homaccord, etc.); dysmenorrhoea (with Spascupreel); amenorrhoea (with Hormeel S); after gynecological haemorrhages (in this case, firstly Cinnamomum-Homaccord N orally and i.m., s.c., i.v.).

Female sterility (combination with Hormeel S and Apis_Homaccord, possibly also Arnica-Heel and Agnus castus-Injeel). As adjuvant experimentally for myomas (in addition: Aurum jodatum-Injeel forte, Hydrastis-Injeel forte and Metro-Adnex-Injeel, possibly also Sulfur-Injeel forte S as mixed injection i.v., as well as Psorinoheel, Strumeel forte, Hormeel S and Galium-Heel). As auxiliary remedy likewise to be tried for alopecia and rosacea (in association with Hormeel S, Cruroheel S and Traumeel  S), as well as for habitual abortion and for frigidity. Especially to be recommended are additional injections of Ovarium compositum.

Gynäcoheel, due to its composition, acts not only in checking inflammation but also exerts a function-regulating influence on the whole female genital sphere, in which case it is combined, according to the indications, with other biotherapeutic agents, several preparations being administered in 1-2-4-hourly alternation or simultaneously. The dosage is adjusted according to the disease, the clinical picture and the stage of the illness: 10 drops 3 times daily before meals. In painful conditions or acute inflammation, initially massive initial-dose therapy of 10 drops every 15 minutes, for 2-3 hours.

An important auxiliary remedy for conditions of gynecological inflammation and functional disorders is Metro-Adnex-Injeel (i.m., s.c., i.v. and over the os sacrum – segmental therapy).

Administration in cases of sterility:

Gynäcoheel 8-10 drops at 8 a.m. and 4 p.m. Hormeel S 8-10 drops at 10 a.m. and 6 p.m.

Apis_Homaccord 8-10 drops at 12 noon and 8 p.m. or 5-10 drops of each of these preparations taken together 2-3 times daily.

If no result is seen, Apis_Homaccord should be exchanged for Arnica-Heel, as well as Ovarium suis-Injeel and Placenta suis-Injeel mixed or alternating once to twice weekly for therapy-resistant functional disorders, in addition.

Tablets _ Injection solution Composition:

Tablets: 1 tablet cont.: Aconitum napellus D4 120 mg; Bryonia cretica D4, Lachesis mutus D12 60 mg each; Eupatorium perfoliatum D3, Phosphorus D5 30 mg each.

Injection solution: 1.1 ml cont.: Aconitum napellus D3 4.4 µl; Eupatorium perfoliatum D2, Phosphorus D4 1.1 µl each; Lachesis mutus D11, Bryonia cretica D3 2.2 µl each. Indications:

Tablets: Influenza and influenzal infections and for the stimulation of the endogenic defence system in other feverish infectious diseases.

Injection solution: Influenza and influenzal infections.

Dosage:

Tablets: In general, 1 tablet to be dissolved under the tongue 3-5 times daily. In acute disorders, 1 tablet every 15 minutes, over a period lasting up to two hours.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v.

Package sizes:

Tablets: Packs containing 50 and 250 tablets.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Aconitum napellus (monkshood)

Chills, influenza; fever with hot, dry skin; neuralgia, inflammatory rheumatism, angina pectoris with anxiety.

Bryonia cretica (bryony)

Inflammation of all serous membranes, coughing when entering a warm room, thirst, rheumatic pains.

Lachesis mutus (bushmaster)

Inattention to worsening condition, accumulation of mucus, e.g. congestive bronchitis, sensation of globus, angina tonsillaris, bluish-red swelling.

Eupatorium perfoliatum (thoroughwort)

Influenzal infections/influenza with pains in the limbs; coughs with excruciating pain in the chest and headaches.

Phosphorus (phosphorus)

Remedy for affections of the parenchyma, bronchopneumonia, laryngitis with hoarseness, damage to the liver parenchyma.

Based on the individual homoeopathic constituents of Gripp-Heel, therapeutical possibilities result for the treatment of influenza and catarrhal influenzal infections in any stage and in patients of any age. Further, other feverish (infectious) diseases such as angina, otitis media, bronchitis, tracheitis, etc.

Irrespective of which particular organotropism (organotropy to the upper parts of the respiratory tract, such as the nose and pharynx, pneumo-, cardio-dermato-, entero- or neurotropy) or which microorganism causing influenza is present, an increase in the body’s own defences is always indicated, which is achieved by means of Gripp-Heel (orally and/or parenterally).

In this connection, in the reversal effect according to Arndt-Schulz, Aconitum exerts a specially stimulating action on the haemoderm (abatement of chilliness), in addition rapidly relieving neuralgic disorders and circulatory lability, while Eupatorium eliminates pains in the joints and the feeling of exhaustion. The content of Lachesis mutus (septic infections, tendency towards haemolysis), Bryonia cretica (thirst, irritation from coughing, retrosternal pain, diseases of the serous membranes such as pleuritis) and Phosphorus (petechiae, elective effect on the lungs in preventing pneumonia) broadens the therapeutical spectrum of Gripp-Heel according to Burgi’s principle, perfecting the preparation effectively. The dosage is adjusted according to the disease, the clinical picture and the stage of the illness: in fever and to cut the disease short, at the start of therapy 1 tablet every 15 minutes for 2-3 hours, after which, transition to 1 tablet 3 times daily. As influenza prophylaxis in periods of epidemic, 1 tablet 3 times daily. In primary or secondary serious stages, in addition 1-2 ampoules daily i.m., s.c., i.d., i.v., preferably mixed with Engystol N and/or with Traumeel S (mixed injections to avoid excessive reactions, i.m. or s.c.), as long as fever remains; possibly intermediate injections of Echinacea compositum S.

The intradermal neural application of Gripp-Heel is particularly indicated for  pains in the joints. For children, it is recommended that only i.m. or s.c. injections of Gripp-Heel ampoules should be given.

Drops _ Injection solution Composition:

Drops: 100 g cont.: Graphites D10, Graphites D30, Graphites D200, Calcium carbonicum Hahnemanni D10, Calcium carbonicum Hahnemanni D30, Calcium carbonicum Hahnemanni D200 0.5 g each. Contains 35vol.-% alcohol.

Injection solution: 1.1 ml cont.: Graphites D10, Graphites D30, Graphites D200, Calcium carbonicum Hahnemanni D10, Calcium carbonicum Hahnemanni D30, Calcium carbonicum Hahnemanni D200 5.5 µl each.

Indications:

Eczema, particularly dry, chronic; for long-term therapy in the case of scars and keloids.

Dosage:

Drops: In general, 10 drops 3 times daily. Long-term administration of the preparation (for several months) must be supervised by a therapist.

Injection solution: In general, 1 ampoule i.m., s.c., i.d., i.v., 1-3 times weekly.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Graphites (graphite)

Tendency towards adiposis, chronic (especially atonic) constipation; dry, cracked skin, but also eczema with honey-yellow crusts; eczema of the auditory meatus, chronic inflammation of the outer eye, chalazions.

Calcium carbonicum Hahnemanni (the inner white part of the oyster shell)

Pasty appearance, rickets, scrofulosis, exudative diathesis, sudation of the occiput; cold, moist feet; infantile facial eczema, petechial eruptions; wounds which will not heal, easily ulcerating.

Based on the individual homoeopathic constituents of Graphites-Homaccord, therapeutic possibilities result for its application as alternative constitutional remedy for exudative diathesis, adiposis and other deposition phases of the mesenchyma; it is also indicated for lipomas, atheromas, ganglions and especially for keloids. Experimentally for the long-term treatment of chronic-atonic constipation.

In skin diseases it is also recommended, if no action is observed quickly, to administer other Heel biotherapeutics in addition at intervals, such as Lamioflur, Psorinoheel and especially those with a certain reactive effect (Schwef-Heel, Sulfur-Heel), particularly for irritated, hypersensitive skin, intertrigo, dermatitis and eczema, as well as for neurodermatitis (in addition to Acidum fumaricum-Injeel and other acids of the citric acid cycle). For tinnitus aurium the combination with Barijodeel, Osteoheel S or also Cruroheel S, as well as with Suis-organ preparations (Os petrosum suis-Injeel and Funiculus umbilicalis suis-Injeel, etc.) is advantageous; experimentally for coxitis.

The dosage is adjusted according to the disease, the symptoms and the stage of the illness: 10 drops 3-4 times daily; in treatment continuing through months, at intervals  10 drops only once daily. 1 ampoule 1-3 times weekly i.m., s.c., i.v., possibly with other auxiliary remedies indicated.

INJECTION SOLUTION
Composition: 2.2 ml containing: Methylglyoxalum D10, Glyoxalum D10 22 mg each.

Indications:
Stimulation of the defensive mechanisms against toxins in blocked and defective enzymatic systems, disturbed glandular functions, degenerative diseases (cellular phases).

Dosage:
Standard dosage: Adults (and children 12 yrs. and older): 1 ampoule 1 to 3x weekly.
Glyoxal compositum injection solution may be administered by the s.c., i.d., i.m. or i.v. route.

Note:
If the patient briefly experiences temperature rise or local pain after administration, this should be interpreted as a positive response to therapy. These reactions should, however, be allowed to subside before repeated injection.

Package sizes:
Packs containing 10 and 100 ampoules of 2.2 ml each. (8521)

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Pharmacoclinical notes

Methylglyoxalum D10 (a glyoxyl with the addition of a methyl group):
A key reactive intermediate that is an α-oxoaldehyde (also termed an α-dicarbonyl) formed as an early glycation end product partly from the nonenzymatic reaction between reducing sugars and amine residues on proteins, lipids, and nucleic acids; can be formed from the spontaneous degradation of glucose during short periods of hyperglycemia, as can occur in impaired glucose tolerance; also can be formed from catabolism of ketone bodies and threonine, as well as from breakdown of triosephosphates; finally, can be formed from tobacco smoke and diet, especially with prolonged heating of food products. It is metabolized to D-lactate in a process that requires glutathione; unlike glyoxal, it also can be formed in an enzymatic process, such as from aldose reductase and glyoxalase reactions, and has 4 different pathways that can be involved in its detoxification.

It has well-established roles in the development of complications of diabetes; the development of advanced glycation end products (AGEs) is accelerated by hyperglycemia; these products accumulate in the sites, such as the retina, kidney, and atherosclerotic plaques, that are the most common sites for damage from diabetic complications.

Involved in the development of diabetic peripheral neuropathy, nephropathy, ocular disease, atherosclerotic disease, cardiomyopathy, and peripheral arterial disease; possibly provides the link between hyperglycemia and immune suppression; in particular, it is a potent suppressor of myeloid and T-cell immune function, such as the loss of interferon-a and interleukin 10.

AGEs also might activate monocytes to increase the expression of adhesion molecules and promote the production of cytokines and the proliferation of T cells. AGEs have been linked to the development of chronic diseases, such as the retinopathy, neuropathy, and nephropathy associated with long-term diabetes mellitus, macrovascular disease, Alzheimer disease, cataracts, and premature aging.

AGEs act through their receptor, which is termed receptor for AGEs (which is an immunoglobulin superfamily receptor) or via cross-links of the extracellular matrix to promote the oxidative stress and proinflammatory signaling components contributing to the neuronal and vascular complications of long-term diabetes. AGEs also directly cross-link type I collagen and elastin proteins of the vascular walls to increase vascular stiffness and resistance to proteolytic degradation and promote cardiovascular complications, as well as cross-link with myelin, tubulin, plasminogen activator, and fibrinogen to promote further intracellular and extracellular damage.

The composition of the extracellular matrix is modified by AGEs, with an increased expression of certain proteins, such as fibronectin, types III, IV, and VI collagen, and laminin, as well as through the upregulation of transforming growth factor-β and connective tissue growth factor; is cytotoxic to neuroglial cells.

Glyoxalum D10:
An α-oxoaldehyde formed as an early glycation end product from the product of the nonenzymatic glycosylation of proteins; can be formed from the spontaneous degradation of glucose during short periods of hyperglycemia, as can occur in impaired glucose tolerance; also can be formed in lipid peroxidation; is part of the AGE-receptor for AGE process previously described for methylglyoxalum.

Glyoxal and methylglyoxal are members of the carbonyl group series. According to Prof. W. F. Koch, they have the ability to depolymerize toxic material by acting as a hydrogen receptor. The same action is seen with the quinones. Glyoxal is one of the dangerous by-products of abnormal glucose metabolism in diabetics and is implicated in the formation of the so-called AGEs. These are immunogenic and stimulate an inflammatory response, which leads to tissue destruction. Glyoxal in a D10 may facilitate the excretion of this glyoxal and protect the tissues. Furthermore, through the carbonyl group, it acts as a hydrogen receptor, resulting in the formation of free radicals. Intracellular free radicals are especially dangerous to cancer cells, because they have poor antioxidant protection. Glyoxal was classically used infrequently, and only repeated when its action had worked. However, in modern homotoxicology, it is often used in a much more frequent manner because of the increase in intoxication and the dysregulation of modern patients.

References

1. Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 1999;344(pt 1):109-116.
2. Cerami C, Founds H, Nicholl I, et al. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A. 1997;94(25):13915-13920.
3. Vlassara H, Cai W, Crandall J, et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002;99(24):15596-15601.
4. Arribas-Lorenzo G, Morales FJ. Analysis, distribution, and dietary exposure of glyoxal and methylglyoxal in cookies and their relationship with other heat-induced contaminants. J Agric Food Chem. 2010;58(5):2966-2972.
5. Vander Jagt DL, Hunsaker LA. Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase. Chem Biol Interact. 2003;143-144:341-351.
6. Vander Jagt DL. Methylglyoxal, diabetes mellitus and diabetic complications. Drug Metab Drug Interact. 2008;23(1-2):93-124.
7. Goh SY, Cooper ME. Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008;93(4):1143-1152.
8. Price CL, Knight SC. Methylglyoxal: possible link between hyperglycaemia and immune suppression? Trends Endocrinol Metab. 2009;20(7):312-317.
9. Price CL, Hassi HO, English NR, Blakemore AI, Stagg AJ, Knight SC. Methylglyoxal modulates immune responses: relevance to diabetes. J Cell Mol Med. 2010;14(6B):1806-1815.
10. Ohashi K, Takahashi HK, Mori S, et al. Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction. Clin Immunol. 2010;134(3):345-353.
11. Negre-Salvayre A, Salvayre R, Augé N, Pamplona R, Portero-Otin M. Hyperglycemia and glycation in diabetic complications. Antioxid Redox Signal. 2009;11(12):3071-3109.
12. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932-943.
13. Vlassara H. Advanced glycation end-products and atherosclerosis. Ann Med. 1996;28(5):419-426.
14. Throckmorton DC, Brogden AP, Min B, Rasmussen H, Kashgarian M. PDGF and TGF-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products. Kidney Int. 1995;48(1):111-117.
15. Twigg SM, Cao Z, McCarthy DJ, et al. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology. 2002;143(12):4907-4915.
16. Lee HK, Seo I, Suh DJ, Lee HJ, Park HT. A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells. J Neurochem. 2009;108(1):273-284.
17. Koch WF. The Survival Factor in Neoplastic and Viral Diseases. Publisher unknown; 1961.
18. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia. 2001;44(2):129-146.

Drops

Glonoin-Homaccord®

Injection solution Composition:

Drops: 100 g cont.: Glonoinum D3, Glonoinum D10, Glonoinum D30, Lycopus virginicus D1, Lycopus virginicus D4, Lycopus virginicus D10, Lycopus virginicus D30 0.1g each; Crataegus Ø 60 g. Contains 45 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Glonoinum D4, Glonoinum D10, Glonoinum D30, Lycopus virginicus D2, Lycopus virginicus D4, Lycopus virginicus D10, Lycopus virginicus D30 1.1 µl each; Crataegus D4 8.8 µl. Indications:

Tachycardia, particularly with excessive secretion of the thyroid gland; anginous disorders.

Dosage:

Drops: In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, over a period lasting up to two hours. Long-term application of the  preparation (over several months or longer) must be supervised by a therapist.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Glonoinum (nitroglycerol)

Palpitations extending to the neck, a sense of impending death, anginal disorders. Lycopus virginicus (gypsy-wort)

Hyperthyroidism with tachycardia and nervous coronary disorders. Crataegus (whitethorn)

Pre-insufficiency, coronary insufficiency, senile heart, focal-toxic/infectious myocardial weakness, general sedative.

Based on the individual homoeopathic constituents of Glonoin-Homaccord, therapeutic possibilities result for the treatment of tachycardia, particularly of hyperthyroidism, anginal disorders with radiating pain (in the arm, breast, abdomen and neck). In these cases Glonoin-Homaccord acts, in addition to Cralonin, Cardiacum-Heel (as massive initial-dose therapy for disorders) and Aurumheel N drops (for signs of slight decompensation), not only symptomatically but also, with long administration, to provide a lasting cure. Glonoin-Homaccord can also be used harmlessly for a fairly long time. In glaucoma as auxiliary remedy, in plethora and polycythaemia in addition to Nux vomica-Homaccord and possibly Melilotus-Homaccord. The dosage is adjusted according to the disease, the symptoms and the stage of the illness: in acute disorders 5-10 drops every 10-15 minutes until improvement, possibly alternating with the above- mentioned preparations. For long-term therapy, 10 drops 3 times daily. 1 ampoule i.v. for an attack in sporadic disorders, otherwise 1 ampoule i.m., s.c., i.v. 1-3 times  weekly, possibly with Cralonin, Angio-Injeel, Tabacum-Injeel, Aconitum-Injeel S, Carbo vegetabilis-Injeel, is rapidly effective, possibly also after myocardial infarction, together with Traumeel S, Carbo compositum, Strophanthus compositum, etc.