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Guna Index
- Allergology
- Anti Ageing and Regenerative Medicine
- Dermatology
- Gastroenterology
- Clinical Immunology
- Aesthetic Medicine
- Preventive Medicine
- Opthalmology
- Pediatrics
- Rheumatology
- Pain Therapy
- We believe that every patient is first of all a man
who suffers. - We think that health is not just absence of disease.
- We believe that man is mind, body and spirit.
- We think it is possible to act on the causes and
symptoms of the disease together. - We think that it is possible to offer drugs without
negative side effects. - We think that Nature is the most extraordinary
“pharmaceutical industry”. - We think that a Medicine that understands the intimate mechanisms of both Biology and human Physiology is able to develop a new generation of drugs: innovative, effective, respectful of the human being and in harmony with Nature
Per minima ad maxima
Since 1994, Guna S.p.a. has invested significant financial and intellectual resources, first in studying a new therapeutic concept, then in research and development of those pharmacological principles that are the cornerstones of a new vision of Medicine. The results of pre-clinical and clinical research studies have put Guna in the limelight because of the interest of both Italian and international scientific community, thus accelerating the company’s worldwide expansion.
Low Dose Medicine (LDM) was born from Guna’s ideal of a human-centered Medicine, in harmony with Nature. LDM is a new medical paradigm developed from the merging of Molecular Biology, Psycho-Neuro-Endocrine-Immunology (PNEI) and the great tradition of the homeopathic method.
LDM is a person-centered Medicine, based on three concepts drawn from the principles of classical homeopathy:
- to treat the person and not just the disease
- to act on the cause and not just on the symptom
- to consider a person as a whole, and in his/her individuality
Low Dose Medicine stems from an original idea in the medical field: to bring back a sick organism to its original physiological conditions by using natural substances derived from herbal, animal, mineral sources, as well as those biological molecules that are normally present in the body and that, in healthy conditions, monitor and guide body’s physiological functions. These molecules are called signaling molecules and they are cytokines, hormones, neuropeptides and growth factors.
Set in the conceptual framework of Low Dose Medicine, Guna pharmacology has allowed to develop two main product lines:
- Medicines containing low doses of single cytokines, hormones, growth factors or neuropeptides
- Multi-component, multi-target medicines (combining signaling molecules with remedies derived from herbal, mineral, and animal sources)
Since the 1970s, research studies in the fields of Physiology and Molecular Biology have highlighted the critical role of signaling molecules in all physiological and pathological processes. It is acknowledged that these substances play a decisive role in determining a state of health or illness, and it is now established that every disease is the expression of an altered concentration, i.e. an excess or a deficiency, of these substances. Many international medical research studies are focused on studying signaling molecules and their role in determining the positive (healing) or negative (progression) evolution of a great number of pathological conditions, and therefore the possibility of using them for therapeutic purposes.
Moreover, in the last years the medical field has undergone a gradual shift from the separatist and scotomized vision of body’s biological functions, giving way to a more unified vision, according to the guiding principles of Psycho-Neuro-Endocrine-Immunology (P.N.E.I.) [1–4]. The P.N.E.I. approach represents a real paradigm shift in Medicine: from a strictly biomedical and specialized view of health and disease to a deeply interdisciplinary one. The key for understanding the P.N.E.I. approach is the cross-talk between the psycho-neuro-endocrine systems and the immune system.
Figure 1:
P.N.E.I. network and bi-directional cross-talk between the systems.
This sophisticated cross-talk [14–16] is mediated by a complex network of signaling molecules:
- cytokines
- hormones
- neuropeptides
- growth factors
These are the vehicle of the biological information necessary for such a complex and efficient regulation of cellular responses to stimuli. An altered cross-talk due to an imbalance between specific signaling molecules is fundamental, for example, in the onset of inflammatory, allergic and autoimmune diseases [5–7]. Restoring the physiological concentration of signaling molecules is the key point to recover the homeostatic balance.
Homeostatic Conditions
In homeostatic conditions (corresponding to a healthy state), the concentrations of these molecules in the extra-cellular matrix (ECM) [8–9, 17–18] are comprised in a specific physiological range (from nanograms/ml to picograms/ml) [19–20] and diseases can be considered as expressions and consequences of an altered concentration of these fundamental substances [10–13].Figure 2:
Range of physiological concentration of signaling molecules at the level of the extracellular matrix.
The signaling molecules used in LDM are orally administered and their activity is systemic (working on complex cell signaling pathways). Scientific literature reports that cytokine oral intake is effective in modulating immune response [21–24] and that a possible action mechanism involves M cells at the level of intestinal epithelium.
A critical point of signaling molecules (and peptides in general) oral administration
is represented by their low bioavailability (typically less than 1–2%); an effective drug delivery system is requested in order to improve this key parameter.The use of physiological low doses (nanograms–picograms) (Figure 2) per os in LDM
is made possible by the application of SKA technology (Sequential Kinetic Activation), a particularly sophisticated drug delivery system, based on the principles of quantum physics (“release activity”: ability of the basic substance to release its activity in the aqueous milieu) [25], which allows the nano-concentrations to be active, even below the actually considered minimum effective dose, with therapeutic results comparable to those induced by high concentrations.The action mechanism of low dose SKA cytokines, hormones, neuropeptides and growth factors
consists in the sensitization or activation of some units of cellular (or plasmatic) receptors in virtue of their high dilution, i.e. in their physiological working range between 10⁻⁶ molar (microgram) for hormones [8] and 10⁻¹² molar (picogram) for the other signaling molecules [9] (Figure 4). This receptor sensitization allows the trigger of chain reactions (complex systems) and a restart of the biological function of the whole P.N.E.I. network. Low dose SKA molecules work by providing information able to activate autoregulation mechanisms.
Figure 3: Relationship between signaling molecules concentration and their effects.
Based on these assumptions, from a clinical point of view, the therapeutic approaches are:
- To restore the homeostasis of a pathologically down-regulated cellular pathway administering the same cytokine, hormone, neuropeptide or growth factor (low dose SKA) that is physiologically involved in the cellular signaling;
- To use antagonistic molecules (low dose SKA) in order to down-regulate the molecules pathologically up-regulated, restoring their homeostatic concentration via negative feedback mechanisms, according to the principle of “opposing” molecules.
The ability to correct, for example, alterations of the immune system by using cytokines or endocrine disorders by using hormones, represents one of the most fascinating and innovative challenges in Molecular Biology applied to Medicine. Unfortunately, the clinical application of this knowledge has always been brought to a standstill by the side effects that these substances show when used in high doses, i.e., those normally used until now.
From a pharmacological point of view, Guna multi-component, multi-target medicines show their typical integrative soul, as they are the result of a blend between homeopathic tradition and Molecular Biology, with the aim of achieving a positive clinical outcome (Figure 4).
It is easy to understand the formulation of Guna medications: Although each product has specific fields of application, each composition shows a common structure which represents a holistic medical approach to acute and chronic diseases.
Guna multi-component, multi-target medications are unique, due both to their ingredients and their relating dilutions. These medications are designed based on a standard common philosophy, i.e. to be effective on both inherent causality and symptoms of the disease. (Figure 5).
The ingredients of each single Guna formulation are assembled and balanced in a unique combination, a powerful therapeutic unit whose components act together in order to restore body’s balance and to cure the disease.
Figure 4: The structure of Guna complexes
Guna multi-component, multi-target medicines are produced in the following pharmaceutical forms:
- Drops for oral use
- Pellets for oral use
- Globules for oral use
- Oral solution
- Nasal spray
- Oromucosal spray
- Injectable solution
Figure 5: Guna multi-component, multi-target medicines are effective on both inherent causality and symptoms of disease.
A
Antibiotics (Supportive therapies during antibiotic therapy)
Appendicitis, chronic (alongside allopathic therapy)
Attention Deficit Hyperactivity Disorder (ADHD)
Auto Immune Disease (pain symptomatology)
B
C
Calcium Metabolism, disfunction of
Cerebral Lesions; partial, fetal, in early childhood
Charcot’s disease See Intermittent Claudication
Chronic Fatigue Syndrome (CFS/ME)
Chronic Obstructive Pulmonary Disease (COPD)
Crohn’s Disease (ileitis and colitis)
D
De Quervain’s Disease (Tendosynovitis)
E
Esophagitis See also Gastro-Esophogeal Reflux Disease.
F
G
Gangrene, diabetic, arteriosclerotic (atherosclerotic)
Gastro-Esophageal Reflux Disease (GERD)
H
Helminthiasis (Parasitic Infection)
Herniated Intervertebral Disc (post surgical treatment)
Herpes Zoster (Post Herpetic Neuritis)
I
Interdigital mycosis (Athlete’s Foot)
Intermittent Claudicatio (Charcot’s disease)
J
K
L
Liver Damage and Liver Cirrhosis
Lymphadenitis and Lymphangitis
Lymph system insufficiency (Lymphatic Congestion)
M
N
O
Oophoritis (Ovarian Inflammation, Pelvic Inflammatory Disease)
P
Periarthritis, Humeroscapular (Frozen Shoulder)
Polyarthritis, symptomatic treatment
Q
R
S
Shoulder-hand syndrome (Brachial Neuritis)
T
Toning, total body (Aesthetic Medicine)
U
Urinary Tract Infection, acute
Urinary Tract Infection, chronic
V
W
X
Y
Z
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Dr Reckeweg Index
The ever increasing interest in biological therapy encourages us to reveal to a larger number of Pracfitioners the method of how to use our Speclalities, these having been developed as a resulf of Dr.Reckeweg’s experiences in the flelds of homoeopathy, blology and popular therapy.The remedles have been subjected to constant Improvements over many years and are known worldwlde for their high quality and efficlency.
The secret of the efficacy of the remedies lies in the carefully selected compositions In accordance with principles of homoeopathy, the use of more than one antidote has been avoided. On the other hand, the pairing of ingredients with similar compensating effects has been encouraged. In this way their field of efficacy has been enlarged, their aggressiveness increased and therapeutic results assured.
The “pure” homoeopath tries to control a disease with the least possible number of remedies, For the Practitioner who Is Inexperienced in this type of therapy it is quite a laborious and time-consuming undertaking to get acquainted with the homoeopathic pharmacopoela and to select that remedy which is most likely to ensure success. So, it is, therefore, of enormous advantage to have a remedy athis disposal that makes this task unnecessary but enables him to practice Biological Therapy.
Our preparations take Into consideration the most important symptoms in a given condition and may, therefore, be used with utmost confidence in accordance with the listed indications. They exert their influences by animating the healing forces inherent in the organism. For the blologically Interested Practitioner we have listed a few of the more prominent symptoms for each Individual ingredient. In this way,the novice gains insight into the princlples underlying homoeopathic thinking.
By using our speclalities, the Practitioner may perhaps form a bridge between prescribed medication and biology; which today an every increasing number of Doctors are desirous of crossing, and In turn giving patients a wider choice.
Dr. Reckeweg – Homoeopathic Specialities
R1 Inflammation drops
R2 Gold drops
R3 Heart drops
R4 Diarrhoea drops
R5 Stomach drops
R6 Influenza drops
R7 Liver and gallbladder drops
R8 Jutussin Cough syrup
R9 Jutussin Cough drops
R10 Menopausal drops
R11 Rheuma drops
R12 Calcification drops
R13 Haemorrhoidal drops
R14 Nerve and sleep drops
Vita-C 15 Relaxant
Vita-C 15 forte Quincefor Nerve tonic, forte version
R16 Migraine and neuralgia drops
R17 Regeneration drops
R17F Regeneration drinking ampoules
R18 Kidney and bladder drops
R19 Glandular drops for men
R20 Glandular drops for women
R21 Reconstituant drops
R22 Drops for nervous disorders
R23 Eczema drops
R24 Pleurisy, intercostal neuralgia
R25 Prostatitis
R26 Draining and stimulating drops
R27 Renal calculi drops
R28 Dysmenorrhea, amenorrhea
R29 Vertigo, syncope
R30 Universal ointment
R31 Energizes the appetite
R32 Hyperhidrosis of varying genesis
R33 Constitutional treatment in epilepsy
R34 Recalcifying drops
R35 Teething aches drops
R36 Diseases of the nerves
R37 Intestinal drops
R38 Ovaries, right side
R39 Ovaries, left side
R40 Treatment of diabetes
R41 Sexual neurasthenia drops
R41F Sexual neurasthenia drops
R42 Inflammation of the veins
R43 Asthmatic constitution
R44 Low blood pressure
R45 Hoarseness / larynx
R46 Rheumatism of forearms and hands
R47 Hysteric complaints
R48 Pulmonary weakness
R49 Acute and chronic catarrh, sinusitis
R50 Gynecological sacroiliac complaints
R51 Thyroid intoxication
R52 Vomiting, nausea, travel sickness
R53 Acne vulgaris
R54 Memory weakness
R55 All kinds of injuries
R56 Vermifuge
R57 Pulmonary tonic
R58 Stimulates the renal function
R59 Obesity
R60 Blood impurities
R61 Rheumatic ointment
R62 Inflammation of mucous membranes
R63 Drops for impaired circulation
R64 Albuminuria drops
R65 Psoriasis drops
R66 Cardiac arrhythmia drops
R67 Drops for circulatory debility
R68 Herpes drops
R69 Intercostal neuralgia
R70 Neuralgia drops
R71 Sciatica drops
R72 Pancreas drops
R73 Drops for the joints
R74 Drops for nocturnal enuresis
R75 Dysmenorrhoea drops
R76 Asthma forte drops
R77 Anti-smoking drops
R78 Eye drops for oral administration
R79 Heart Capsules
R80 Arnica Oil for topical use
R81 Analgesic dropsGeneral Instructions Regarding the Use of Our Specialities
The drops are to be taken in a teaspoonful of water and always on an empty stomach. If 3 times daily is indicated, the first dose should be taken in the morning on an empty stomach, the second at noon before mealtime, and the third one before retiring. If a more frequent medication is indicated, then the additional doses should be spread evenly over the day. If there is no improvement after several days of medication, the dose may be increased without hesitation. The more acute a condition is, the more often the medicament can be taken at the beginning of treatment.
The use of our remedies awakens the curative forces inherent in the organism. There is no reason for fearing injurious results, even from over-medication.
A correct interpretation of the auto-curative effort of the organism permits a practitioner to observe and guide this restorative attempt in quite a new and unique manner. The same applies to acute fever conditions in which the organism reacts with increased eagerness to any type of outside help which is meant to assist the body in its efforts to get well again. When, in spite of frequent application of our remedies in acute infections accompanied by high fever, there has been no apparent improvement after a period of 24 hours, then it will be noticed that the additional use of penicillin at this time is more likely to assure control of the infection and hasten recovery, as the addition of these biologic stimulants elicits from the organism a more effective mobilisation of its defensive forces. In most infections, the additional use of such medicaments will not be necessary.
The application of our biological remedies does not involve a one-sided principle, but an attempt to awaken in the organism healing forces which have hitherto hardly ever been taken into consideration. It would be wrong to underrate this importance. In many chronic conditions, already after a few days, the patient will feel he is now on the way to recovery.
Any additional information required will be gladly given by us. On the other hand, we would be only too glad to hear from doctors who may have had new or unique experiences in the use of our remedies.
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Clinical Immunology Index
The correlation between Cytokines, Hormones, Neuropeptides and Growth Factors located right of the table – with their symptoms, syndromes and pathological conditions:
Abdominal pain (cramp-like) INTERLEUKIN-5 4CH Abdominal swelling INTERLEUKIN-11 4CH Acute and chronic stress INTERLEUKIN-8 4CH Acute inflammatory diseases Anti INTERLEUKIN-1alpha 4CH / Anti INTERLEUKIN-1beta 4CH Aging INTERLEUKIN-2 4CH / FGF 4CH / IGF-1 4CH / PDGF 4CH / ACTH 6DH / Beta-ESTRADIOL 6DH / FSH 6DH / LH 6DH Allergic syndromes INF-gamma 4CH+INTERLEUKIN-12 4CH Allergies INTERLEUKIN-12 4CH + INTERFERON-gamma 4CH / INTERLEUKIN-13 4CH Allergy-induced hyperlacrimation INTERLEUKIN-12 4CH Appetite disorders (excessive appetite) INTERLEUKIN-1 beta 4CH / INTERLEUKIN-6 4CH Appetite control CNTF 4CH Articular pain INF-alpha 4CH Articular symptoms (painful-degenerative) with limited movement FGF 4CH Asthenia INTERLEUKIN-1 beta 4CH / INTERLEUKIN-7 4CH / INF-alpha 4CH / INF-gamma 4CH / ACTH 6DH / PARATHYROID HORMONE 6DH Asthenia and drowsiness INTERLEUKIN-9 4CH Autism BDNF 4CH Autoimmune diseases TGF-beta 1 4CH Basic regulation in patients undergoing immunotherapy INTERLEUKIN-11 4CH Basic therapy for autoimmune diseases INTERLEUKIN-4 4CH Blurred vision with scintillating scotomas EGF 4CH Bone pain CALCITONIN 6DH Bruise-induced pain INTERLEUKIN-5 4CH Burning sensation in the mouth INTERLEUKIN-2 4CH Catarrh INTERLEUKIN-8 4CH Cerebral aging BDNF 4CH / CNTF 4CH Chapped skin EGF 4CH Chemotaxis activation INTERLEUKIN-8 4CH Chronic bacterial infections TNF-alpha 4CH Chronic catarrh INTERLEUKIN-9 4CH Chronic fatigue syndrome DOPAMIN 6DH Chronic inflammations TGF-beta 1 4CH Chronic inflammatory diseases INTERLEUKIN-4 4CH / INTERLEUKIN-10 4CH Chronic pain syndromes INTERLEUKIN -10 4CH / Beta-ENDORFINA 4CH / TGF-beta 1 4CH Chronic viral infections INF-gamma 4CH Chronic stress ACTH 6DH Cicatrisation difficulty FGF 4CH Circadian rhythm and organ function alterations MELATONIN 4CH CNS and PNS diseases NT3 4CH / NT4 4CH Complementary treatment for tumours SOMATOSTATIN 4CH / INTERLEUKIN-12 4CH / INTERFERON-gamma 4CH / INTERLEUKIN-2 4CH / MELATONIN 4CH / TNF-alpha 4CH Confusion at night with sleep disorders TNF-alpha 4CH Constipation and flatulence INTERLEUKIN-5 4CH Cramp-like pain PARATHYROID HORMONE 6DH Crohn’s Disease INTERLEUKIN-10 4CH + Anti IL-1 Damage to the myelin sheath G1 4CH Decreased sexual arousal DOPAMIN 6DH Decreased sexual satisfaction OXYTOCIN 6DH Diet disorders SEROTONIN 6DH Digestive disorders INTERLEUKIN-3 4CH Drud addiction DOPAMIN 6DH Early aging INTERLEUKIN-3 4CH Erratic pain INTERLEUKIN-3 4CH Erythroid proliferation disorders (synergy with erythropoietin) INTERLEUKIN-9 4CH Feeling of heaviness in the epigastrium with soreness EGF 4CH Female hormone cycle disorders and infertility Beta-ESTRADIOL 6DH / FSH 6DH / LH 6DH / PROGESTERON 6DH Fever Anti IL-1 4CH Food intolerances INTERLEUKIN-12 4CH Gastric acid hypersecretion EGF 4CH General sickness INTERLEUKIN-2 4CH / INTERLEUKIN-6 4CH Growth and development disorders INTERLEUKIN-7 4CH / INTERLEUKIN-11 4CH Growth disorders IGF-1 4CH / T4 6DH Headache SEROTONIN 6DH Haemopoiesis disorders INTERLEUKIN-3 4CH / INTERLEUKIN-11 4CH Hypersensitivity to pain EGF 4CH Hyperparasympathicotonia ACTH 6DH Hypersympathicotonia MELATONIN 4CH Hyperthyroidism SOMATOSTATIN 4CH Hypothyroidism T3 6DH Hot flushes Beta-ESTRADIOL 6DH Immune response triggered in chronic and autoimmune diseases GCSF 4CH Immunodeficiencies INTERLEUKIN-2 4CH Intermenstrual spotting PROGESTERON 6DH Intestinal parasitosis INTERLEUKIN-5 4CH Itching EGF 4CH Itching and burning sensation INTERLEUKIN-10 4CH Jet lag MELATONIN 4CH Lack of attentiveness DOPAMIN 6DH Lack of sexual desire DOPAMIN 6DH Localised inflammations INTERLEUKIN-2 4CH Loss of appetite ACTH 6DH Loss of strength in limbs, easy tiredness NGF 4CH Low female libido FSH 6DH / OXYTOCIN 6DH / DOPAMIN 6DH Low male libido LH 6DH / DOPAMIN 6DH Memory disorders NGF 4CH / IGF-1 4CH (stimulates hippocampus function) / INTERLEUKIN-11 4CH Memory loss INTERLEUKIN-3 4CH Menstrual pain PROGESTERON 6DH Mental fatigue INTERLEUKIN-4 4CH Mental strain DOPAMIN 6DH Mental tiredness BDNF 4CH / G1 4CH Mood disorders NGF 4CH / NT3 4CH / NT4 4CH / OXYTOCIN 6DH / DOPAMIN 6DH Mood disorders and unstable mood MELATONIN 4CH / SEROTONIN 6DH / TRYPTOPHAN 6DH Muscle weakness G1 4CH / NT3 4CH / NT4 4CH / PROLACTIN 6DH Myalgia and sti fness especially in the morning TNF-alpha 4CH Mytogenic activity PDGF 4CH Nasal obstruction and nose itch INTERLEUKIN-12 4CH Nervous breakdown and tiredness INTERLEUKIN-7 4CH / INTERLEUKIN-11 4CH Neuralgic pain NGF 4CH / INTERLEUKIN-9 4CH Neuroasthenia T4 6DH / TSH 6DH Neurological damage (during development or subsequent to injuries) BDNF 4CH / CNTF 4CH / NT3 4CH / NT4 4CH Osteoporosis CALCITONIN 6DH Outcome of psychic shock BDNF 4CH Ovarian polycystosis FSH 6DH / PROGESTERON 6DH Pain of diverse origins Beta-ENDORPHIN 4CH Pain syndromes Beta-ENDORPHIN 4CH / Anti INTERLEUKIN-1 4CH / NT4 4CH Painful muscular spasms INF-alpha 4CH Paroxysmal sneezing INTERLEUKIN-12 4CH Physical asthenia T4 6DH Pulsating pain INTERLEUKIN-7 4CH / INTERLEUKIN-11 4CH Premenstrual syndrome PROGESTERON 6DH / Beta-ENDORPHIN 4CH Productive cough INTERLEUKIN-8 4CH Psoriasis INTERLEUKIN-11 4CH / INTERLEUKIN-4 4CH / INTERLEUKIN-10 4CH Pyrosis and gastric acid hypersecretion INTERLEUKIN-11 4CH Recurrent infections INTERLEUKIN-7 4CH Recurrent nighttime cough INTERLEUKIN-12 4CH Recurrent viral infections INF-alpha 4CH Red mucous membranes INTERLEUKIN-10 4CH RRI with IgA deficiency INTERLEUKIN-5 4CH Sadness and loss of interest NGF 4CH Sagging skin Beta-ESTRADIOL 6DH Sensitivity to infectious diseases GCSF 4CH Sensitivity to viral infections INTERLEUKIN-2 4CH Side effects of chemotherapy, radiotherapy and antiviral treatments INTERLEUKIN-3 4CH Sight disorders CNTF 4CH Skin eruptions INTERLEUKIN-3 4CH Skin aging EGF 4CH / FGF 4CH Skin rashes EGF 4CH Skin thinning and ulcers NGF 4CH Sleep disorders MELATONIN 4CH / TRIPTOPHAN 6DH / INTERLEUKIN-1 beta 4CH Social phobia OXYTOCIN 6DH Spastic cramp-like pain INTERLEUKIN-4 4CH Spastic muscle pain INF-gamma 4CH Stiff muscles BDNF 4CH Stress BDNF 4CH / Beta-ESTRADIOL 6DH / MELATONIN 4CH Subacute pain syndromes INTERLEUKIN-2 4CH / Beta-ENDORPHIN 4CH Sudden pain with numbing INF-alpha 4CH Supportive treatment during delivery OXYTOCIN 6DH Supportive treatment of Autism OXYTOCIN 6DH Supportive therapy of Pakinson’s disease DOPAMIN 6DH Swollen and reddened skin INTERLEUKIN-12 4CH Tendency toward overweight T3 6DH Tingling sensation and numbness in hands and feet BDNF 4CH Vertigo with vomiting INTERLEUKIN-3 4CH Vomiting – loss of appetite INTERLEUKIN-10 4CH Water retention INTERLEUKIN-9 4CH / TSH 6DH Weariness, adynamia INTERLEUKIN-2 4CH Wrinkles PDGF 4CH -
Heel Veterinary Index
A
Abscess of the anal gland in dogs
Aggressive behaviour from anxiety
Auditory canal, inflammation of the
B
Basal metabolism rhythm, to increase the
Bone callus, rapid formation of
C
Calcium metabolism, disturbance of the
Cardiotonic, postoperative or after infections
Cerebral irritation, states of
COB (Chronic obstructive bronchitis)
Collapse, states of; Phlebitis
Coronary circulation disorders
Cycle, functional disorders of
D
Defense, stimulation of the endogenous
Dictyocaulus viviparus, protostrongylosis, metastrongylosis
Disorders of the brain function
Displacement of the fourth stomach
E
Enteritis through enterovirus or parvovirus
F
Foreign bodies in the digestive system
G
H
Hemorrhage brought on by physical effort
Hepatic function, stimulation of
I
J
K
L
M
Massage, treatment after training or physical strain
Maxillae, bone swelling and exostosis
N
Necrosis, avascular (Morbus Perthes)
Non-specific stimulation of the defense
O
P
Palpation or rectal exploration, spasms during
Panleucopenia, feline (as palliatives in)
Paralysis of the shoulder in horses
Perianal glands, inflammation of the
Q
R
Rectal exploration or palpation, spasms during
Regeneration, therapy for general
Respiratory tract, diseases of the
Rhinotracheitis, infectious bovine
S
Shock, symptoms of post-traumatic
Skin diseases of varying etiology
Palpation or rectal exploration, spasms during
Stimulation of the endogenous defense
T
Tenesmus of the urinary system
Trichomoniasis (Adjuvant therapy)
Trichophytosis (Adjuvant therapy)
U
V
Vomiting (without organic findings)
Vulvovaginitis, pustular, infectious
X
Y
Z
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Heel Index
Homotoxicosis is a non-physiological condition which arises after reaction of a homotoxin on cells and tissues. A homotoxicosis occurs as a humoral or cellular phenomenon and can be followed by morphological alterations on tissues. The homotoxicosis is named after the homotoxin which triggers it and leads to defensive measures by the organism whose goal is the elimination of the homotoxins and restoration of the physiological conditions when possible.
This refers to the local regulation possibilities of the ground system along with its super- imposed nervous, hormonal and humoral regulation systems. The ground system is composed of the ground substance plus cellular, humoral and nervous components. The ground substance (extracellular matrix) is formed of highly polymerized sugars (proteoglycans and glycosaminoglycans) plus structural and meshing glycoproteins.
The six-phase table (Figure 1) illustrates the chronological courses of various symptoms of a disease within the framework of the ground regulation. The individual phases are transient into each other and demonstrate typical phase-indicating signs. The six-phase table is subdivided into three sections (humoral phases, matrix phases, cellular phases) each of which contains two phases. The biological division runs within the matrix phases.
The humoral phases
In the humoral phases the intracellular systems are not disturbed. The defense system is intact and can excrete the homotoxins via various paths.
- Excretion phase: This phase contains manifestations of increased physiological excretion mechanisms.
- Inflammation phase: Illnesses of this phase are marked by an exudative inflammation that enables an accelerated excretion of toxins from the body.
The matrix phasesIn these phases, for the first time, the homotoxins are deposited in the mesh of the extracellular matrix. Through time its structural components and functions are altered. In the case of continuing illness, increasing stress and damage of the intracellular structures result.
- Deposition phase: In this phase the excretion mechanisms of the body are overworked and toxins are deposited in the matrix. This phase often progresses with few symptoms.
- Impregnation phase: Diseases in this phase are characterized by the presence of toxins which become a part of the connective tissue and the matrix, along with changes in the structural components and their function. The typically increasingly severe symptoms of this phase demonstrate damage of the organ cells.
The cellular phasesDuring the cellular phases of a disease, cell systems are increasingly destroyed. The defense system is no longer able to excrete the toxins from the cells or out of the matrix by virtue of its own strength. Typical for these patients is the so-called ‘regulation rigidity.’
- Degeneration phase: During this phase, courses of disease cause serious damage, and destruction of larger cell groups of an organ occur.
- Dedifferentiation (neoplasm) phase: Diseases of this phase are characterized by the development of undifferentiated, non-specialized cell forms. Malignant diseases stand at the end of this phase.
The biological division refers to the imaginary boundary between the deposition and impregnation phases. It demarcates the pure deposition in the matrix from the integration of toxins into its structural components. Whereas a simple excretion of toxins is possible during the deposition phase, structural and functional changes are found in the impregnation phase. Thus, the spontaneous endogenic excretion of homotoxins is impeded.
The term ‘vicariation’ refers to the transition of the indicating signs of an illness within one phase to another organ system, or the change of fundamental symptoms into another phase with or without a change of the organ system.
Progressive vicariation refers to an aggravation of the total symptoms of an illness.
Regressive vicariation refers to an improvement of the total symptoms of an illness.
The different components of the anti-homotoxic preparations activate the defense system of the body. The immune system with its memory and regulation systems can be compared to the spiritual-mental self, the ego. The deposition phase and more frequently the impregnation phase are characterized by immunological processes such as chronic inflammation and auto-aggression. The humoral area (via immunoglobulins from B-lymphocytes) and the cellular area (T-cells, granulocytes, macrophages) still counterbalance each other in this case. A regressive vicariation is still possible in these matrix phases.
Herein lies a great opportunity for anti-homotoxic medicine. The immunological bystander reaction represents a theory of anti-homotoxic therapy for inflammatory illnesses. It is based on low dose antigen reactions, particularly of substance combinations in the range of 1X to 14X, with 4X to 8X appearing to be the most favorable. The bystander effect cannot be triggered at higher potencies. Experience shows that higher potencies as well as trace elements and intermediary catalysts are able to stimulate the ground regulation. (Functional circle of anti-homotoxic therapy; Heine 1997.) It is significant that for the potency ranges 3X to 12X, a considerable difference exists in the activation of specific enzyme systems compared to substances conventionally diluted to the same concentration. The dose-action relationship of potentized substances compared to diluted substances demonstrates a non-linear relationship.Every organism requires energy to maintain its vital functions which must be continuously provided by the metabolism. Disorders of the energy metabolism, therefore, impair the energy supply which is controlled by endogenic regulation. The organism is an energetically open system for which suitable energy, in the form of food, must be supplied and unsuitable energy must be evacuated. In this manner an unstable state of order can be maintained, far from a thermodynamic balance, for a longer period of time; a “life- span.” All reactions of the organism proceed at relatively low temperatures in the aqueous milieu and must be accelerated, i.e., catalyzed. The prerequisite for an effective catalysis is suitable substrates between and in the cells. Because the extracellular space is located in front of the cells, the cells can only react as they have been informed via the extracellular space. The dynamic structure of the extracellular space and its regulation (ground regulation) have therefore a decisive impact on the effectiveness of the extracellular and intracellular catalysts. This depends on the structure of the ground substance (extracellular matrix or simply, matrix). It forms in all cells and cell groups a molecular sieve of matrix components such as highly polymerized sugar protein complexes and sugar complexes (proteoglycans-glycosaminoglycans, PG/GAG’s), structural proteins (collagen, elastin) and meshing glycoproteins (e.g., fibronectin) (Figure 2). As the PG/GAG’s are electro-negatively charged, they are able to bind water and exchange ions as well. They are therefore the guarantors for isoiony, isoosmy and isotony in the matrix.
ground substance, terminal autonomic axons, connective tissue cells (mast cells, defense cells, fibroblasts, etc.) and parenchyma cells. Epithelial and endothelial cell groups rest on a basal membrane which mediates to the ground substance. Every cell surface carries a glycoprotein and glycolipid film connected to the ground substance (dotted line), to which the histocompatibility complexes (MHC) also belong. The ground substance is connected to the endocrine system via the capillary system and via the axons to the central nervous system. The fibroblast is the metabolically active center (Heine, 1997.)
The connection to the central nervous system is conducted via the autonomic nerve fibers blindly ending in the matrix. The connection to the system of endocrine glands (pituitary gland, thyroid gland, suprarenal gland, etc.) is conducted via the capillary system which permeates the matrix. Both systems are connected to each other in the brainstem and to superimposed centers of the brain. In this manner, the matrix is regulated not only on site but also under the influence of superimposed control areas. The regulation center in the matrix is the fibroblast (corresponding to the glia cell in the central nervous system). It reacts immediately to all incoming information (hormones, neural substances, metabolites, catabolites, pH value changes, etc.) with a synthesis of ‘good’ or ‘bad’ information. In this manner every surplus or deficit can lead in certain circumstances to detrimental consequences for the total system depending individually on a vicious cycle.
It is important to note that due to the sieve-like as well as connective properties of the PG/ GAGs, the danger of damaging the matrix also exists through the development of a latent tissue acidity, increase of free radicals and the activation of the proteolytic system turning into a pro-inflammatory situation. Ultimately, damage of all humoral and cellular elements may arise progressing at first from persistent feelings of ill health to chronic disease and malignant processes (Heine, 1997.)
Homotoxicological remedies have the ability to achieve immunomodulation. This immunomodulation is achieved via ingredients in the remedies used; these remedies contain an amino acid sequence in dilution, therefore remedies with plant extracts, suis organ extracts, nosodes and animal venoms are able to immunomodulate. The critical dilution of the ingredients from 1X-14X, furthermore gives the remedies the ability to induce the immunological bystander reaction, primarily in the Gut Associated Lymphoid Tissue (GALT) and less so in the peripheral tissues.
The normal immune response depends, apart from the non-specific immune response via the phagocytes, complement and acute phase proteins, on the specific immune response, mediated by the lymphocytes and their products.
The CD4, CD8 and the family of Large Granular Lymphocytes (Including the Natural Killer Cells) forms part of this normal arm of the immune response. The CD4 and CD8 cells need to be activated by an Antigen Presenting Cell (APC) which will present the antigen by processing it either via the Major Histocompatibility Complex I or II (MHC I or II) or via other molecules such as the CD1 molecule in the intestinal epithelial cell. MHC I will activate CD8 cytotoxic cells, MHC II the CD4 helper cells and CD1 from the Intestinal Epithelial Cells (IECs) will activate CD8 suppressor cells.
CD4 cells have several subclasses of functional cells, namely Th1, Th2, Th3 and also Th4 cells. Th1 cells secrete the cytokines TNF and Interferon gamma and will activate lymphocytes and products which have significance within cellular immunity. Under pathological conditions, Th1 cells will cause diseases like Rheumatoid arthritis, Inflammatory bowel disease and other organ related autoimmune diseases such as Multiple sclerosis. It is also responsible for the general inflammatory processes we see in the tissues in general. Th2 cells on the other hand secrete the cytokines IL-4, 10, 5, and 13 and have significance within antibody formation. Th2 cells are also the pathway through which allergic phenomena are mediated in pathological circumstances. In the normal organism, there is a constant oscillation between Th0, Th1 and Th2 cells and this oscillation has a chronobiology similar to most of our other regulatory systems. In factTh1/Th2 oscillation is under the control of the neuroendocrine system, and will follow its diurnal rhythm. Another mechanism which achieves this Th1/Th2 oscillation is the inhibitory effect the Th1 and Th2 secreted cytokines will have on each other. Another cell which can also modulate the normal oscillation is the Th3 cell.
This cell secretes the cytokine Transforming Growth Factor beta, (TGF-ß) and can modulate the balance between Th1/Th2. In addition the Th3 cell and certain CD8 suppressor cells are most likely responsible for the development of our immune tolerance to foods. It seems that the size of the antigen which is presented by the APC will determine whether it will generate a Th1, Th2 or Th3 response. According to Heine, any substance in the dilution from 1X-14X will have the effect of generating a Th3 response, and to a lesser extent, a Th2 response.
This refers, as its name implies, to the induction of cells by a relative non-toxic antigen which will then have an effect on a process such as an inflammation which was started by another antigen somewhere else in the body. Let’s look at the bystander reaction (Figure 3).
Figure 3: The bystander reaction
In order to initiate the bystander reaction we need a small dose of antigen, or a remedy containing plant extract, suis organ extract, animal venom or a nosode, each in a specific dilution. These diluted substances are then taken up by the APC’s in the gut lining which will present them as an antigen to the lymphocytes in the GALT via the MCH or the CD1 binding mentioned above. The processed antigen is then displayed as a motif on the outside of the APC. There will be a motif for each of the ingredients, thus if we give Traumeel, one for Arnica, one for Bellis perennis, etc., or if we give Hepar compositum, one for Hepar Suis, one for Colon Suis and so forth.
After being presented with the motifs on the APC, prolymphocytes of the Th3 type are activated due to the size of the motif (5-15 amino acids), and will differentiate into a population of Th3 cells. There will be a Th3 type cell for each of the motifs presented, thus one for Arnica, Bellis perennis and so forth.
These lymphocytes then migrate to the lymph nodes in the Peyer’s patches and proliferate into billions of copies. This process is called cloning.
The millions of cloned Th3 cells will then through chemotaxis find the inflammation caused by Th1, Th2 and Th4 lymphocytes and suppress them, thereby restoring the balance and normal oscillation between Th1/Th2 cells. Here the law of similars is at work, as each Th3 cell for Arnica or Bellis perennis for instance, will find the corresponding Th1/Th2 cell which looks similar to its motif and suppress it.
The immunological bystander reaction serves as a model for the working mechanism of immunomodulatory remedies which, through a non-toxic substance in a specific dilution can induce a regulatory cell, the Th3 cell . This regulatory cell, while developed at another site, and acting as an innocent bystander can bring about a balance in the immune system, by down-regulating an inflammatory process started by another noxious homotoxin remote from its own activation. The Th3 cell acts as a fulcrum on which the balance of Th1 and Th2 cells rests (Figure 4).
This also confirms one of the ways which Dr. Reckeweg postulated as to how homotoxicological remedies work. He theorized that by giving a non-toxic substance the defense system of the body is activated through another pathway in order to bring about homeostasis.
Figure 4: Diagram of Th3 as a fulcrum
Due to the dilution and ingredients found in certain homotoxioclogical remedies they lend themselves well to this type of immunoregulation.
A
Attention Deficit Hyperactivity Disorder (ADHD)
B
C
Calcium metabolism, symptoms of
Cerebral lesions; partial, fetal, in early childhood
Chorea minor (Sydenham’s chorea)
Chron’s disease (ileitis and colitis)
Chronic Fatigue Syndrome (CFIDS)
Chronic obstructive pulmonary disease (COPD)
Claudication, intermittent (Charcot’s disease)
Complex regional pain syndrome
D
Dermatomycosis (ringworm of the nails)
Dumping syndrome (post-gastrectomy)
Dyslipidemia (mild to moderate)
Dyspepsia (gastric indigestion)
E
Ecthyma (pyogenic skin infection)
Enuresis nocturna (bed wetting)
Epithelioma (epithelia neoplasm)
Eustachian tube blockage (catarrh of the ear)
Excitation, conditions of hyperactivity
F
Fibroma of the breast (fibrocystic breast disease)
Flatulence (See also Abdominal bloating)
G
Gangrene, diabetic, arteriosclerotic
Gastro-Esophogeal Reflux Disease (GERD)
Glossitis (inflammation of the tongue)
H
I
Inoculation damage (post-vaccination symptoms)
Inoculation damage (prophylaxis of)
J
K
L
Lateral sclerosis, amyotrophic
Liver damage and cirrhosis of the liver
Lymphadenitis and lymphangitis
M
Mononucleosis, infectious (glandular fever)
Muscular dystrophy, progressive
Myocardial infarction (as auxiliary remedies)
N
Nephrolithiasis (kidney stones)
Neurogenic hypotension (orthostatic hypotension)
O
P
Pelvic Inflammatory Disease (P.I.D.)
Periartheritis calcaria (myositis ossificans)
Q
R
S
Sheehan’s syndrome (pituitary insufficiency)
Shock, conditions of, traumatic
Stroke (hemorrhagic or embolic)
Sudoresis of the feet (excessive perspiration)
T
Thrush (mucocutaneous candidiasis)
Thyroidectomy (cervical syndrome)
U
Urinary tract infection, acute
Urinary tract infection, chronic
V
W
X
Y
Z
-
Pharmacological Index
A
B
C
D
E
F
G
H
I
K
L
M
N
O
P
R
S
T
U
V
Y
Z
The Course of Therapy
By introducing the vicariation principle into antihomotoxic therapy, Reckeweg pointed out the dynamics of every disease and/or recovery process. The interrelationships which exist between a bio-system and the damaging homotoxins vary continuously during an illness and during the recovery process. The purposeful, self-regulatory forces of the organism usually are retained during illnesses up to and including phases of the six-phase table of homotoxicosis. In contrast, after the Biological Division is crossed, from phase 4 onward, self-regulation and self-recovery is practically no longer possible for the organism. In this case a therapeutic treatment is required to achieve recovery. Following regressive vicariation, a disease often enters phase 2 or 3. This typically requires a change of the antihomotoxic preparation because in phase 2 a symptomatically indicated acute remedy is usually necessary. In phases 2 and 3, which belong to the humoral phases, the self- regulatory capacity of the organism is still present, so that only stimulative medication is required to initiate inflammatory mechanisms, particularly in the matrix. Usually the excretion of the disease occurs via the skin or the mucous membranes. Increased perspiration, sputum, strong formation of urine, light diarrhea and fever are welcome signs of a shift out of the cellular disease phases which indicates an improvement of the basic illness. In the acute phases 1 and 2, composita preparations such as Traumeel or certain Homaccords are preferable.
Dosage Forms of the Preparations
Homeopathic remedies prepared in solid form are in most cases mixed with milk sugar (lactose) and then formed into tablets. Tablets should be placed under the tongue and allowed to dissolve gradually without chewing. This permits the active ingredients to be absorbed through the buccal lining of the mouth, thereby evading the stomach where gastric juices might destroy or inactivate the remedy.
Liquid homeopathic mediciations should be retained in the mouth long enough for their contents to be absorbed by the mouth’s buccal lining. As with tablets, the goal is to avoid the stomach’s juices which can inactivate the remedy. Therefore, liquids should not be simply swallowed.
Topical preparations offer a direct application to the affected area. Ointments and gels may be applied generously, as necessary, by rubbing gently into the skin.
Homeopathic nasal sprays are not associated with side effects or the risk of habituation. To thoroughly coat the nasal membranes, inhale deeply through each nostril after application.
Suppositories offer an alternate route of administration for persons unable to take medications orally.
For comfort in administering, warm the liquid by holding the vial in a closed hand for one minute.
Homeopathic eye drops are safe for wearers of contact lenses.
Homeopathic cough syrups help promote expectoration to shorten the duration of the cough.
The injection solution offers doctors the ability to inject medication directly into the affected area. Remedies are contained in vials and diluted in an isotonic sodium chloride solution base.
-
Heel Therapeutic Index
Classical homeopathy according to Hahnemann (1811) orients itself based on the so-called ‘drug picture’ to determine the appropriate remedy. It claims that symptoms of disease behave reciprocally towards those symptoms which the healthy test person develops after the intake of a mother tincture or a diluted substance (potency.) The principle of action which can be derived thereof is known as the Simile Principle (Similia similibus curentur = Likes may be cured by likes.) The clinical syndrome occurring in a patient can be overcome by an artificially induced, similar disease. The Aequalia Principle (Isopathy = the condition may be healed by the causative substance) can also be applied with potentised allopathic substances or partly with nosode preparations in anti-homotoxic medicine and/or with vaccines in conventional medicine.
Classical homoeopathy works with single remedies which are only partly truly single- constituent remedies, (e.g., sulphur, mercury, arsenic, etc.), or which are otherwise botanical extractions containing a highly complex mixture of numerous constituents. Repertories (lists of symptoms produced by drugs) facilitate the selection of the most appropriate remedy in homoeopathy.
Anti-homotoxic medicine usually pursues an indication-oriented approach. The anti- homotoxic remedies predominantly represent mixtures of substances of low to middle potencies. Through practical application in homoeopathy it became obvious that the use of concentrated or poisonous tinctures could damage the patient and that, therefore, they could only be used in homoeopathic dilutions, i.e., potencies. This practice was scientifically supported by Rudolf Arndt (psychiatrist, 1835-1900) and Hugo Schulz (pharmacologist, 1853- 1932) through a quantitative differentiation of the medicinal effect on bio-systems and still applies as the Arndt-Schulz Principle. It states:
- weak stimuli stimulate the life functions (retro-action of homoeopathic preparations)
- moderately strong stimuli accelerate them
- strong stimuli act as inhibitors
- the strongest stimuli suspend the life functions
Since several tissue-incompatible substances are usually involved during the development of a disease, the simultaneous use of several potentised ”antitoxins“, as present in the anti- homotoxic preparations, is justified.
Against the background of the conflicting medicinal and therapeutic concepts promulgated in humoral pathology, cellular pathology, molecular pathology, and related fields including modern cybernetics, the German physician Dr. Hans-Heinrich Reckeweg formulated Homotoxicology in 1952. This conception was developed from homoeopathy for the purpose of providing a holistic perspective on the synthesis of medical science.
Reckeweg formulated an essential tenet of Homotoxicology, as follows:
”According to Homotoxicology all of those processes, syndromes, and manifestations, which we designate as diseases, are the expression thereof that the body is combating poisons and that it wants to neutralize and excrete these poisons. The body either wins or loses the fight thereby. Those processes, which we designate as diseases, are always biological, that is natural teleological processes, which serve poison defence and detoxification.“
Referring to conventional medical indications connects anti-homotoxic medicine with allopathy, while therapy with potentised substances unites it to homoeopathy. Anti-homotoxic medicine is the connecting link between allopathic medicine and homoeopathy.
Fig. 1
Conventional medicine:
The higher the concentration, the stronger the effect (dose-effect relation; increase of side effects).
Homoeopathy:
Increase of the effect with decreasing concentration (effect optimum not definable). Anti-homotoxic medicine:
Connecting link between conventional medicine and homoeopathy.
Homotoxins
Homotoxins are all of those substances (chemical/ biochemical) and non-material influences (physical, psychical), which can cause ill health in humans. Their appearance results in regulation disorders in the organism. Every illness is due therefore to the effects of homotoxins. Homotoxins can be introduced from the exterior (exogenic homotoxins) or originate in the body itself (endogenic homotoxins).
Homotoxons
These are understood as chemical reaction products from compounds of homotoxins with each other or with other substances (e.g., products of metabolism) which neutralize the poisonous property of the homotoxins. The best example thereof is the liver, in whose cells homotoxins and metabolic products are united to detoxify the organism.
Retoxins
Deposits of homotoxins with endogenic substances, which cannot be eliminated via excretion or irritation, are designated as ”residual poisons“ (retoxins). The most important example thereof is the non-enzymatic glucosilisation of tissues and cell surfaces in case of glucose excess, as with, among others, latent diabetes mellitus.
Homotoxicosis – The Concept of Disease in Homotoxicology
Homotoxicosis is a non-physiological condition which arises after reaction of a homotoxin on cells and tissues. A homotoxicosis occurs as a humoral or cellular appearance and can be followed by morphological changes on tissues. The homotoxicosis is named after the homotoxin which triggers it. The homotoxicosis leads to defensive measures of the organism whose goal is to eliminate the homotoxins and to restore the physiological conditions when possible.
The Ground Regulation
This refers to the local regulation possibilities of the ground system along with its superimposed nervous, hormonal, and humoral regulation systems. The ground system is composed of the ground substance plus cellular, humoral, and nervous components. The ground substance (extracellular matrix) is formed of highly polymerised sugars (proteoglycans and glycosaminoglycans) plus structural and meshing glycoproteins.
The Phase theory
The Six-Phase-Table illustrates the chronological courses of various symptoms of a disease within the framework of the ground regulation. The single phases are transient into each other and demonstrate typical phasal indicating signs. The Six- Phase-Table is subdivided into three sections (humoral phases, matrix phases, cellular phases), each of which is subdivided into 2 phases. Two phases are allocated to the excretion principle (phases 1 + 2), the deposition principle (phases 3 + 4), and the degeneration and/or deterioration principle (phases 5 + 6). The Biological Division runs within the matrix phases.
Fig. 2: The Six-Phase-Table
The humoral phases
In the humoral phases the intracellular systems are not disturbed. The defence system is intact and can excrete the homotoxins via various paths.
Excretion Phase This phase contains manifestations of increased physiological excretion mechanisms. Reaction Phase Illnesses of this phase are marked by an exudative inflammation, which enables an accelerated excretion of toxins from the body. The matrix phases
In these phases the homotoxins are deposited at first in the mesh of the extracellular matrix. During the further course its structural components as well as functions are altered. In case of continuing illness increasing stress and damage of the intracellular structures result.
Deposition Phase In this phase the excretion mechanisms of the body are overworked and toxins are deposited in the matrix. This phase often progresses with few symptoms. Impregnation Phase Diseases in this phase are characterized by the presence phase of toxins which become a part of the connective tissue and the matrix, along with changes in the structural com- ponents as well as their functions. The typically increasingly severe symptoms and signs of this phase demonstrate damage of the organ cells. The cellular phases
During the cellular phases of a disease, cell systems are increasingly destroyed. The defence system is no longer able to excrete the toxins out of the cells or out of the matrix by virtue of its own strength. Typical for these phases is the so-called regulation rigidity.
Degeneration Phase During this phase, courses of disease cause serious damage, and destruction of larger cell groups of an organ takes place. Dedifferentiation (neoplasm) Phase Diseases of this phase are characterized by the development of undifferentiated, non-specialized cell forms. Malignant diseases stand at the end of this phase. The Biological Division refers to the imaginary boundary between the deposition and impregnation phases. It demarcates the pure deposition in the matrix from the integration of toxins into its structural components. Whereas a simple excretion of the toxins is possible during the deposition phase, structural and functional changes are found in the impregnation phase. Thus the spontaneous endogenic excretion of the homotoxins is impeded.
The term ”vicariation“ refers to the transition of the indicating signs of an illness within one phase to another organ system, or the change of the fundamental symptoms and signs into another phase, with or without a change of the organ system.
Progressive vicariation: Progressive vicariation refers to an aggravation of the total symptoms and signs of illness.
Regressive vicariation: Regressive vicariation refers to an improvement of the total symptoms and signs of an illness.
The different components of the anti-homotoxic preparations activate the defense system of the body. The immune system with its memory and regulation systems can be compared to the spiritual-mental self, the ego. The deposition phase and more frequently the impregnation phase are characterized by immunological processes such as chronic inflammation and auto-aggression. The humoral area (via immunoglobulins from B-lymphocytes) and the cellular area (T-cells, granulocytes, macrophages) still counterbalance each other in this case. A regressive vicariation is still possible in these matrix phases.
Herein lies a great opportunity for anti-homotoxic medicine. The immunological bystander reaction represents a theory of anti-homotoxic therapy for inflammatory illnesses. It is based on low dose antigen reactions, particularly of substance combinations in the range of 1X to 14X, with 4X to 8X appearing to be the most favorable. The bystander effect cannot be triggered at higher potencies. Experience shows that higher potencies as well as trace elements and intermediary catalysts are able to stimulate the ground regulation. (Functional circle of anti-homotoxic therapy; Heine 1997.) It is significant that for the potency ranges 3X to 12X, a considerable difference exists in the activation of specific enzyme systems compared to substances conventionally diluted to the same concentration. The dose-action relationship of potentized substances compared to diluted substances demonstrates a non-linear relationship.Every organism requires energy to maintain its vital functions which must be continuously provided by the metabolism. Disorders of the energy metabolism, therefore, impair the energy supply which is controlled by endogenic regulation. The organism is an energetically open system for which suitable energy, in the form of food, must be supplied and unsuitable energy must be evacuated. In this manner an unstable state of order can be maintained, far from a thermodynamic balance, for a longer period of time; a “life- span.” All reactions of the organism proceed at relatively low temperatures in the aqueous milieu and must be accelerated, i.e., catalyzed. The prerequisite for an effective catalysis is suitable substrates between and in the cells. Because the extracellular space is located in front of the cells, the cells can only react as they have been informed via the extracellular space. The dynamic structure of the extracellular space and its regulation (ground regulation) have therefore a decisive impact on the effectiveness of the extracellular and intracellular catalysts. This depends on the structure of the ground substance (extracellular matrix or simply, matrix). It forms in all cells and cell groups a molecular sieve of matrix components such as highly polymerized sugar protein complexes and sugar complexes (proteoglycans-glycosaminoglycans, PG/GAG’s), structural proteins (collagen, elastin) and meshing glycoproteins (e.g., fibronectin) (Figure 2). As the PG/GAG’s are electro-negatively charged, they are able to bind water and exchange ions as well. They are therefore the guarantors for isoiony, isoosmy and isotony in the matrix.
Figure 2: Diagram of the ground regulation system
Reciprocal relationships (arrows) between capillary system (capillaries, lymph vessels)ground substance, terminal autonomic axons, connective tissue cells (mast cells, defense cells, fibroblasts, etc.) and parenchyma cells. Epithelial and endothelial cell groups rest on a basal membrane which mediates to the ground substance. Every cell surface carries a glycoprotein and glycolipid film connected to the ground substance (dotted line), to which the histocompatibility complexes (MHC) also belong. The ground substance is connected to the endocrine system via the capillary system and via the axons to the central nervous system. The fibroblast is the metabolically active center (Heine, 1997.)
The connection to the central nervous system is conducted via the autonomic nerve fibers blindly ending in the matrix. The connection to the system of endocrine glands (pituitary gland, thyroid gland, suprarenal gland, etc.) is conducted via the capillary system which permeates the matrix. Both systems are connected to each other in the brainstem and to superimposed centers of the brain. In this manner, the matrix is regulated not only on site but also under the influence of superimposed control areas. The regulation center in the matrix is the fibroblast (corresponding to the glia cell in the central nervous system). It reacts immediately to all incoming information (hormones, neural substances, metabolites, catabolites, pH value changes, etc.) with a synthesis of ‘good’ or ‘bad’ information. In this manner every surplus or deficit can lead in certain circumstances to detrimental consequences for the total system depending individually on a vicious cycle.
It is important to note that due to the sieve-like as well as connective properties of the PG/ GAGs, the danger of damaging the matrix also exists through the development of a latent tissue acidity, increase of free radicals and the activation of the proteolytic system turning into a pro-inflammatory situation. Ultimately, damage of all humoral and cellular elements may arise progressing at first from persistent feelings of ill health to chronic disease and malignant processes (Heine, 1997.)
Homotoxicological remedies have the ability to achieve immunomodulation. This immunomodulation is achieved via ingredients in the remedies used; these remedies contain an amino acid sequence in dilution, therefore remedies with plant extracts, suis organ extracts, nosodes and animal venoms are able to immunomodulate. The critical dilution of the ingredients from 1X-14X, furthermore gives the remedies the ability to induce the immunological bystander reaction, primarily in the Gut Associated Lymphoid Tissue (GALT) and less so in the peripheral tissues.
The normal immune response depends, apart from the non-specific immune response via the phagocytes, complement and acute phase proteins, on the specific immune response, mediated by the lymphocytes and their products.
The CD4, CD8 and the family of Large Granular Lymphocytes (Including the Natural Killer Cells) forms part of this normal arm of the immune response. The CD4 and CD8 cells need to be activated by an Antigen Presenting Cell (APC) which will present the antigen by processing it either via the Major Histocompatibility Complex I or II (MHC I or II) or via other molecules such as the CD1 molecule in the intestinal epithelial cell. MHC I will activate CD8 cytotoxic cells, MHC II the CD4 helper cells and CD1 from the Intestinal Epithelial Cells (IECs) will activate CD8 suppressor cells.
CD4 cells have several subclasses of functional cells, namely Th1, Th2, Th3 and also Th4 cells. Th1 cells secrete the cytokines TNF and Interferon gamma and will activate lymphocytes and products which have significance within cellular immunity. Under pathological conditions, Th1 cells will cause diseases like Rheumatoid arthritis, Inflammatory bowel disease and other organ related autoimmune diseases such as Multiple sclerosis. It is also responsible for the general inflammatory processes we see in the tissues in general. Th2 cells on the other hand secrete the cytokines IL-4, 10, 5, and 13 and have significance within antibody formation. Th2 cells are also the pathway through which allergic phenomena are mediated in pathological circumstances. In the normal organism, there is a constant oscillation between Th0, Th1 and Th2 cells and this oscillation has a chronobiology similar to most of our other regulatory systems. In factTh1/Th2 oscillation is under the control of the neuroendocrine system, and will follow its diurnal rhythm. Another mechanism which achieves this Th1/Th2 oscillation is the inhibitory effect the Th1 and Th2 secreted cytokines will have on each other. Another cell which can also modulate the normal oscillation is the Th3 cell.
This cell secretes the cytokine Transforming Growth Factor beta, (TGF-ß) and can modulate the balance between Th1/Th2. In addition the Th3 cell and certain CD8 suppressor cells are most likely responsible for the development of our immune tolerance to foods. It seems that the size of the antigen which is presented by the APC will determine whether it will generate a Th1, Th2 or Th3 response. According to Heine, any substance in the dilution from 1X-14X will have the effect of generating a Th3 response, and to a lesser extent, a Th2 response.This refers, as its name implies, to the induction of cells by a relative non-toxic antigen which will then have an effect on a process such as an inflammation which was started by another antigen somewhere else in the body. Let’s look at the bystander reaction (Figure 3).
Figure 3: The bystander reaction In order to initiate the bystander reaction we need a small dose of antigen, or a remedy containing plant extract, suis organ extract, animal venom or a nosode, each in a specific dilution. These diluted substances are then taken up by the APC’s in the gut lining which will present them as an antigen to the lymphocytes in the GALT via the MCH or the CD1 binding mentioned above. The processed antigen is then displayed as a motif on the outside of the APC. There will be a motif for each of the ingredients, thus if we give Traumeel, one for Arnica, one for Bellis perennis, etc., or if we give Hepar compositum, one for Hepar Suis, one for Colon Suis and so forth.
After being presented with the motifs on the APC, prolymphocytes of the Th3 type are activated due to the size of the motif (5-15 amino acids), and will differentiate into a population of Th3 cells. There will be a Th3 type cell for each of the motifs presented, thus one for Arnica, Bellis perennis and so forth.
These lymphocytes then migrate to the lymph nodes in the Peyer’s patches and proliferate into billions of copies. This process is called cloning.
The millions of cloned Th3 cells will then through chemotaxis find the inflammation caused by Th1, Th2 and Th4 lymphocytes and suppress them, thereby restoring the balance and normal oscillation between Th1/Th2 cells. Here the law of similars is at work, as each Th3 cell for Arnica or Bellis perennis for instance, will find the corresponding Th1/Th2 cell which looks similar to its motif and suppress it.
The immunological bystander reaction serves as a model for the working mechanism of immunomodulatory remedies which, through a non-toxic substance in a specific dilution can induce a regulatory cell, the Th3 cell . This regulatory cell, while developed at another site, and acting as an innocent bystander can bring about a balance in the immune system, by down-regulating an inflammatory process started by another noxious homotoxin remote from its own activation. The Th3 cell acts as a fulcrum on which the balance of Th1 and Th2 cells rests (Figure 4).
This also confirms one of the ways which Dr. Reckeweg postulated as to how homotoxicological remedies work. He theorized that by giving a non-toxic substance the defense system of the body is activated through another pathway in order to bring about homeostasis.
Figure 4: Diagram of Th3 as a fulcrum – Due to the dilution and ingredients found in certain homotoxioclogical remedies they lend themselves well to this type of immunoregulation. Homotoxicological medicines have been developed to serve the very specific purpose of restoring regulation in the organism. Although they may appear as being complex homeopathic compositions, they in fact differ in a number of ways from the normal complex prescription, in that they incorporate various dilutions of remedies, as well as potentized catalysts, allopathics and vitamins, for instance. As our knowledge of molecular biology increases we can witness the deep-acting function of these combinations on the body. We classify the remedies according to the origin of the remedy, the combination, as well as the phase in which they will be useful.
The remedies are made up of four pharmacological groups (PG’s):
- The first group is the plant materials (PPG’s). Depending on the dilution, these could have either the dominant, secondary or complementary action in the remedy.
- The second group is the mineral pharmacological group or MPG’s. In the potency they mostly appear in the remedies, they act as functional regulators, modifiers and stimulators.
- The third group is unique to Homotoxicology, and is made up of the catalysts (CPG’s). These are mostly in the 6X-10X dilution range, and will act as modulators and regulators. The CPG’s may contain potentized elements of the Krebs cycle, and carrier enzymes of the respiratory chain such as Ubichinon (Coenzyme Q10). Hormones in potentized form, as levothyroxin and cortisone, can also act as catalysts. Certain other substances including Procainum, Glyoxal and Methyl glyoxal will also stimulate the intermediary metabolism, and are thus classified as catalysts.
- The fourth group is the immunomodulators (IPG’s). Potentized Suis organ extracts, nosodes and also venoms of animal origin act as immunomodulators. These substances will induce Th3 cells and through the immunological bystander reaction will be able to modulate the immune response.
Homotoxicological remedies may also be classified according to the way the above is combined. Five groups stand out for use in the United States:
- The Indication-based Heel remedies: These are primarily composed of PPG’s and MPG’s and are often indication-based, as, for example, Traumeel and Vertigoheel. They can be used for acute as well as chronic conditions, and depending on the chronicity, can be used from days to weeks to months.
- The Homaccords: These are also primarily composed of PPG’s and MPG’s such as Nux vomica-Homaccord (PPG’s) or Phosphor-Homaccord (PPG’s and MPG’s), which are typically present in potency chords, for instance 3X, 6X, 10X, 30X, 200X, and 1000X. The Homaccords are often organotropic, thus they will support the function of a specific organ, and due to the potency chord will have a far-reaching action on the organ. They are often used for a period of time, 12 weeks for instance. Due to their potency chords, they often will not give a first aggravation seen by other homeopathic remedies.
- The Injeels, or Heel remedies: These remedies are like a combination of the indication- based Heel remedy and a Homaccord, and are often directed at treating a specific indication affecting an organ system. The individual components which are normally PPG’s and MPG’s also come in shorter potency chords than the above, for instance, in potency chords to 10X and 30X.
- The Catalysts: These contain substances of the CPG’s mentioned above occasionally with added potentized vitamins and other co-factors of the intermediary metabolism. The catalysts which come in a compositum also may contain PPG’s, MPG’s, as well as IPG’s. They are added as soon as a condition reaches the matrix phases, in other words, once it affects the ground regulation system, and are employed in cycles, as the compositae.
- The Compositae: These remedies have been developed as the ultimate regulators and modulators. They often contain all four PG’s, namely PPG, MPG, CPG and IPG, and therefore lend themselves to treatment of all conditions, but especially to those in the matrix and cellular phases. Sometimes, however, they are also employed in the humoral phases, on an Auto-regulatory system level, like Echinacea compositum, which is an excellent remedy to use in the inflammatory phase. Towards the right of the biological division, they are employed in cycles of five to six weeks, and the result is then assessed as to whether they should be repeated or not. The compositae come in oral vials, and many are also available in oral tablets.
Disease does not arrive on the cellular level overnight. It will start off as dysregulation of the Auto-regulatory system (ARS) and then move to the matrix, or Ground regulation level, (GRS) and lastly will manifest on the cellular level. This will correspond to the humoral, matrix and cellular phases of the six-phase table.
When disease is in the humoral phases, it will often be enough to only employ remedies of the PPG and MPG group, and therefore most Homaccords, Heel remedies and Indication-based Heel remedies will suffice to restore self-regulation in a patient. However, when disease reaches the Ground regulation level, we need to add a catalyst, and when it approaches the cellular level, we need to mostly add an IPG as well. It is important to note that there are Indication-based Heel remedies other than a compositum, for example Gripp-Heel, which contains animal venom, (Lachesis) and therefore will act as an immunomodulator as well. In Lymphomyosot there is a catalyst (Levothyroxin) and an immunomodulator (Aranea diadema). The latter can thus be employed in all the phases of the six-phase table, whereas a remedy such as Engystol (Vincetoxinum and Sulfur, thus PPG, and MPG), will not be sufficient on its own in the matrix and cellular phases. We will then have to add a CPG such as Coenzyme compositum, and for instance, a compositum containing PPG’s, MPG’S, CPG’s and an IPG in some form.
The choice of remedy is thus made on the phase in the six-phase table in which the condition is classified, and on which part of the Auto-regulatory system or the Ground regulation system will need support.
By introducing the vicariation principle into antihomotoxic therapy, Reckeweg pointed out the dynamics of every disease and/or recovery process. The interrelationships which exist between a bio-system and the damaging homotoxins vary continuously during an illness and during the recovery process. The purposeful, self-regulatory forces of the organism usually are retained during illnesses up to and including phases of the six-phase table of homotoxicosis. In contrast, after the Biological Division is crossed, from phase 4 onward, self-regulation and self-recovery is practically no longer possible for the organism. In this case a therapeutic treatment is required to achieve recovery. Following regressive vicariation, a disease often enters phase 2 or 3. This typically requires a change of the antihomotoxic preparation because in phase 2 a symptomatically indicated acute remedy is usually necessary. In phases 2 and 3, which belong to the humoral phases, the self- regulatory capacity of the organism is still present, so that only stimulative medication is required to initiate inflammatory mechanisms, particularly in the matrix. Usually the excretion of the disease occurs via the skin or the mucous membranes. Increased perspiration, sputum, strong formation of urine, light diarrhea and fever are welcome signs of a shift out of the cellular disease phases which indicates an improvement of the basic illness. In the acute phases 1 and 2, composita preparations such as Traumeel or certain Homaccords are preferable.
Tablets
Homeopathic remedies prepared in solid form are in most cases mixed with milk sugar (lactose) and then formed into tablets. Tablets should be placed under the tongue and allowed to dissolve gradually without chewing. This permits the active ingredients to be absorbed through the buccal lining of the mouth, thereby evading the stomach where gastric juices might destroy or inactivate the remedy.
Oral drops and oral vials
Liquid homeopathic mediciations should be retained in the mouth long enough for their contents to be absorbed by the mouth’s buccal lining. As with tablets, the goal is to avoid the stomach’s juices which can inactivate the remedy. Therefore, liquids should not be simply swallowed.
Ointments and gels
Topical preparations offer a direct application to the affected area. Ointments and gels may be applied generously, as necessary, by rubbing gently into the skin.
Nasal sprays
Homeopathic nasal sprays are not associated with side effects or the risk of habituation. To thoroughly coat the nasal membranes, inhale deeply through each nostril after application.
Suppositories
Suppositories offer an alternate route of administration for persons unable to take medications orally.
Ear drops
For comfort in administering, warm the liquid by holding the vial in a closed hand for one minute.
Eye drops
Homeopathic eye drops are safe for wearers of contact lenses.
Cough syrup
Homeopathic cough syrups help promote expectoration to shorten the duration of the cough.
Injection solution (Rx)
The injection solution offers doctors the ability to inject medication directly into the affected area. Remedies are contained in vials and diluted in an isotonic sodium chloride solution base.
A
Abdominal bloating
Abortion, threatened
Abrasions and burns
Abscesses
Achalasia
Acne rosacea
Acne vulgaris
Acrocyanosis
Addison’s disease*
Adenoid hypertrophy
Adhesions
Adiposis dolorosa
Adnexitis
Adrenal atrophy
Aging, premature
Agoraphobia
Albuminuria
Alcoholism
Allergic symptoms
Alopecia areata
Alveolitis
Alzheimer’s disease
Amenorrhea, functional
Anal fissures
Anaphylaxis*
Anemia*
Angina pectoris*
Angina tonsillaris*
Angina, ulceromembranous
Angioedema
Ankylosing spondylitis
Anorexia
Anosmia
Anthrax
Anxiety, symptoms of
Aphtha (canker sores)
Apophysitis
Appendicitis, chronic*
Arrythmia
Arteriosclerosis*
Arthritis (inflammatory, rheumatoid and traumatic)
Arthritis, symptoms of
Arthritis of the hip
Arthropathy
Ascites
Asthenia, neurocirculatory
Asthma, bronchial*
Asthma, cardiac*
Atelectasis*
Atheroma
Athlete’s heart*
Atrial fibrillation
Atrophic gastritis*
Atrophic rhinitis
Atrophic vaginitis
Attention Deficit Hyperactivity Disorder (ADHD)
B
Back pain (lower)
Bacterial growth, disturbed
Balanitis
Bartholinitis*
Basal cell carcinoma
Basedow’s disease
Bechterew’s disease
Benign prostatic hypertrophy
Biliary colic
Blepharitis
Bone cysts
Bronchiectasis
Bronchitis
Bronchopneumonia*
Brucellosis* (undulant fever)
Bruxism (grinding or clenching of the teeth)
Bulbar paralysis, progressive
Burns, minor
Bursitis
C
Calcaneal spur
Calcium metabolism, symptoms of
Carbuncles (boils)
Carcinoma
Cardiac insufficiency,* latent
Cardiospasm
Cataract, symptoms of
Causalgia
Cellulitis, symptoms of
Cerebral injury
Cerebral ischemia
Cerebral lesions; partial, fetal, in early childhood
Cerebrosclerosis
Cerumen, excessive
Cervical headache
Cervicobrachial syndrome
Chalazion
Character disturbances
Chilblains
Chills, tendency towards
Cholangitis, cholecystitis*
Cholecystitis
Cholelithiasis
Cholesteatoma
Cholesterolaemia
Chondroma
Chondropathy
Chorea minor (Sydenham’s chorea)
Chorioiditis
Chorea minor (Sydenham’s chorea)
Chron’s disease (ileitis and colitis)
Chronic Fatigue Syndrome (CFIDS)
Chronic obstructive pulmonary disease (COPD)
Cicatricial keloids
Cirrhosis hepatis
Claudication, intermittent (Charcot’s disease)
Colic
Colitis
Colitis, ulcerative
Complex regional pain syndrome
Concussion, minor
Collagen-vascular diseases
Collapse
Condylomas
Conjunctivitis
Constipation
Contracture, Dupuytren’s
Convulsions
Corneal opacity
Corns
Coronary diseases
Coronary heart disease
Coronary insufficiency*
Cough, croupous
Coughs
Cradle cap (seborrhea)
Cramps
Croupous coughs
Cushing’s syndrome*
Cystic fibrosis
Cystitis
Cysts
D
Dacryocystitis
Decubitus ulcers
Dedifferentiation Phases
Delirium tremens
Dementia
Dental caries
Depression, endogenous
Depression, exogenous
Depression, reactive
Dermatitis, acute
Dermatomycosis (ringworm of the nails)
Dermatosis, chronic
Desquamation
Diabetes insipidus*
Diabetes mellitus*
Diarrhea
Diphtheria*
Diathesis, exudative (swelling tendencies)
Disc prolapse
Dislocations and sprains
Disturbance of development
Dislocations and sprains
Diverticulitis
Diverticulosis
Dizziness
Douglas’ abscess
Down’s syndrome
Dropsy
Dumping syndrome (post-gastrectomy)
Duodenal ulcer
Duodenitis
Dupuytren’s contracture
Dysentery, symptoms of*
Dyslipidemia (mild to moderate)
Dysmenorrhea
Dyspepsia (gastric indigestion)
Dyspnea, functional
Dyspnoea
Dysuria
Dystonia, vegetative
Dystrophia adiposogenitalis
E
Ecthyma (pyogenic skin infection)
Eczema
Eczema, ani
Eczema, baker’s
Eczema, palpebral
Edema
Ejaculation, premature
Elephantiasis
Emaciation
Emphysema
Empyema*
Empyema of the maxillary sinus
Encephalitis*
Endocarditis*
Enteritis
Enuresis nocturna (bed wetting)
Eosinophilic pneumopathy*
Epicondylitis
Epididymitis*
Epilepsy*
Epileptiform conditions
Epistaxis* (nosebleed)
Epithelioma* (epithelia neoplasm)
Equilibrium disturbances
Erysipelas, symptoms of
Erythema multiforme
Erythrasma, symptoms of
Erysipelas
Esophagitis (See also GERD)
Eustachian tube* blockage (catarrh of the ear)
Exanthema, acute
Exanthema, drug
Excitation, conditions of hyperactivity
Excretory pancreatic failure
Exhaustion
Exophthalmos
Exostosis
Extra systole
Eye irritation
F
Facial paresis
Fat intolerance
Fatigue
Fatty infitration of liver
Fever
Fertility, disturbances of
Fibroma
Fibroma of the breast* (fibrocystic breast disease)
Fibromyalgia
Fibrositis
Fistula
Fistulae
Flatulence (See also Abdominal bloating)
Folliculitis
Focal toxicoses
Flittering scotoma
Frigidity (decreased libido)
Funicular neuralgia
Furuncular otitis
Furunculosis
G
Ganglion cyst
Gangrene, diabetic,* arteriosclerotic*
Gastralgia
Gastritis, acute*
Gastritis, atrophic
Gastritis, chronic*
Gastritis, hyperplastic*
Gastrocardiac syndrome
Gastroduodenitis
Gastroenteritis
Gastro-Esophogeal Reflux Disease (GERD)
Gastro-intestinal hemorrhage*
Geriatric indications
Gingival abscesses*
Gingivitis
Glaucoma*
Glaucoma*
Globus hystericus
Glomerulonephritis*
Glossitis (inflammation of the tongue)
Glucose intolerance
Goiter*
Gonorrhea*
Gout
Granulocytopenia*
Granuloma
H
Haemarthrosis
Haematomas
Haemorrhages
Haemorrhagic diathesis
Haemorrhoids
Halitosis
Hay fever (allergic rhinitis)
Headache
Heartburn (esophagitis)
Heel spur
Helminthiasis*
Hemarthrosis
Hematomas
Hemorrhagic diathesis*
Hemorrhoids
Hepatitis*
Hernias
Herpes, simplex and zoster
Hiccoughs
Hoarseness
Hordeolum
Hydrarthrosis
Hydrocele
Hydronephrosis
Hyperacidity
Hyperemesis
Hyperesthesia
Hyperhidrosis
Hyperlipidemia
Hypermenorrhea
Hyperoxaluria
Hypersalivation
Hypertension*
Hypertensive heart disease
Hyperthermia
Hyperthyroidism
Hypochondriasis
Hypoglycemia*
Hypomenorrhea
Hypophyseal insufficiency*
Hypoplasia mammae
Hypotension
Hypothyroidism
Hypotonia
I
Icterus
Ileitis and jejunitis
Immune deficiency
Impetigo*
Impotence, male
Incontinence, anal
Incontinence, urinary
Indigestion
Inertia, uterine
Infarct
Infection*
Infection, chronic, recurrent
Infectious diseases
Infertility
Inflammation
Influenza
Inner ear deafness*
Inoculation damage (post-vaccination symptoms).
Inoculation damage (prophylaxis of)
Insomnia
Insufficiency of lymph ststem
Intercostal neuralgia
Interdigital mycosis
Intermenstrual pain
Intermittent lameness
Intertrigo
Intestinal colic
Intestinal spasms
Intestinal stasis
Iridocyclitis*
Iron deficiency anemia
Irritable bladder
Irritable bowel syndrome
Iritis
Itch
K
Keloids
Keratitis
Keratoderma
Kidney stones
Korsakoff’s psychosis
L
Lactorrhea
Laryngitis
Lateral pharyngitis
Lateral sclerosis, amyotrophic
Lead poisoning*
Lentigo (liver spots)
Leucopenia
Leukoplakia
Leukorrhea
Lichen planus
Lipid metabolism disturbance
Lipoma
Liver abscess*
Liver damage and cirrhosis of the liver*
Liver overload, functional
Lumbago
Lupus erythematosus*
Lymphadenitis and lymphangitis
Lymphadenopathy
Lymphatism
Lymphedema
Lymphogranuloma, inguinal
M
Malaria
Macular degeneration
Malabsorption
Malaise (See also Exhaustion)
Malignant anthrax*
Mania
Mastitis
Mastodynia
Mastoiditis
Measles
Megacolon
Melancholia
Ménière’s syndrome
Meningeal reactions
Meningism
Meningitis
Menopause
Menorrhagia
Menstrual disorders
Meteorism
Metritis, parametritis
Microsporea
Migraine
Milk secretion (to promote)
Mononucleosis, infectious (glandular fever)
Morning sickness
Motion sickness
Multiple sclerosis*
Mumps
Muscular atrophy
Muscular dystrophy,* progressive
Muscular rheumatism
Myasthenia gravis*
Mycosis
Myelitis
Myocardial infarction* (as auxiliary remedies)
Myocarditis*
Myoma uteri (fibroid uterus)
Myopia
Myotonia
Myositis ossificans
Myxedema*
N
Naevi
Nasal polyps
Nephrolithiasis* (kidney stones)
Nephrosclerosis*
Nephrosis
Nephrotic syndrome*
Nervousness
Nervous system imbalances, autonomic
Neuralgia
Neurasthenia
Neuritis, optical
Neurodermatitis
Neuroma of a stump
Neurocirculatory asthenia
Neurodystrophy
Neurogenic hypotension (orthostatic hypotension).
Neuroma
Neurosis
Neurotic depression
Nevi
Nutritional disorders in infants
O
Obesity (adiposis)
Obstetrics (general)
Oedema
Oedema (swelling)
Olfactory and gustatory senses, disturbance of
Onchomycosis
Onychorrhexis
Oophoritis*
Orchitis
Organic psychosis syndrome
Ostealgia
Osteoarthritis
Osteochondrosis
Osteomalacia
Osteomyelitis*
Osteophytes of the heels
Osteoporosis
Otitis externa
Otitis media, acute*
Otoliths
Otorrhea
Otosclerosis
Ovarian cysts
Ovarian insufficiency
Ovaritis
Oxaluria
Ozena
Ozaena
P
Pain
Pancreatic failure, excretory
Pancreatic fibrosis
Pancreatitis*
Papilloma (of the bladder)
Paradentosis
Paralysis*
Paralysis, general*
Parametritis
Paraplegia*
Paresis
Parkinson’s disease*
Paronychia
Pelvic Inflammatory Disease (P.I.D.)*
Pemphigus
Periarteritis nodosa*
Periartheritis calcaria (myositis ossificans)
Periarthritis, humeroscapular
Periarthritis, scapulohumeral
Pericarditis
Peridontosis
Peripheral vascular disease
Peritonitis
Pertussis*
Peyronie’s disease
Pfeiffer’s disease
Pharyngeal tonsils, hypertrophy of
Pharyngitis
Phlebitis
Phobias
Pityriasis versicolor
Plantar fasciitis
Plethora
Pleurisy*
Pneumoconiosis
Pneumonia*
Pneumopathy, eosinophilic
Polyarthritis
Polyneuritis
Polyneuropathy
Polyposis coli
Polyps
Polyuria
Porphyria*
Precancerous dermatitis
Precancerous state
Premenstrual syndrome
Proctitis, periproctitis
Prolapse, anal and rectal
Prolapsus ani et recti
Prolapsus uteri
Prolapse, uterine
Prostatic hypertrophy, benign
Prostatitis
Pruritus
Psittacosis
Psoriasis
Psychic symptoms
Pulmonary fibrosis
Pulmonary hemorrhage
Pulmonary tuberculosis
Pulpitis
Purpura hemorrhagica
Pyelitis and pyelonephritis*
Pylorospasm
Q
Quinsy*
R
Radiation sickness
Ranula (sublingual cysts)
Reactive depressive syndrome
Recto-uterine abscess*
Reiter’s syndrome
Renal atrophy
Renal edema*
Renal failure*
Renal secretions, disturbance of
Restless leg syndrome
Reticulocytosis
Retinal detachment*
Retinitis
Retinitis pigmentosa*
Retroflexion, uterine
Rhagades
Rheumatoid arthritis
Rhinitis
Rhinitis, acute
Rhinitis, allergic
Rhinophyma
Rhinorrhea
Rickets*
Ringworm of the nails
Roemheld’s syndrome
Rosacea
Rubella
Rubeola morbilli
S
Salpingitis
Scabies
Scarlatina
Schizoid conditions
Sciatica
Scleritis
Scleroderma
Scotoma*
Scrofulosis
Scurvy
Sebacious cyst (adenoma)
Seborrhea
Senile heart*
Sheehan’s syndrome* (pituitary insufficiency)
Shingles
Shock, conditions of, traumatic*
Shoulder-hand syndrome
Sicca syndrome
Siderosis
Silicosis
Simmond’s disease
Sinus-empyema
Sinusitis
Sinusitis, acute
Sinusitis, chronic
Sjögren’s syndrome
Sleep disturbances
Smoker’s lung
Snake bite*
Solar dermatitis
Spasms
Speech disorders
Spinal paralysis, spastic*
Spondylosis
Sports injuries
Sprains
Stasis, venous
Status asthmaticus
Status epilepticus
Stenocardia
Sterility
Stomatitis aphthosa
Strangury
Stress
Stroke* (hemorrhagic or embolic)
Struma
Strumectomy, condition after
Stumps, painful
Styloiditis (radii)
Subluxations*
Sudeck’s atrophy
Sudoresis of the feet (excessive perspiration)
Sunburn
Sunstroke
Suppuration
Sural spasms
Sweat glands, disorders of
Synovitis
T
Tabes dorsalis (tertiary syphilis)
Tachycardia, paroxysmal
Tears, excessive
Telangiectasia
Tendosynovitis
Tendovaginitis
Tenesmus of the G-I tract
Tenesmus of the urinary tract
Tennis elbow
Testicular atrophy
Tetany
Therapeutical damage
Thrombangitis obliterans
Thrombocytopenia
Thrombophlebitis
Thrush (mucocutaneous candidiasis)
Thyrotoxicosis
Thyroidectomy (cervical syndrome)
Thyroiditis
Tibia, pain in
Tic, convulsive
Tinnitus aurium
TMJ Syndrome
Tongue, burning sensation of
Tongue, condition of
Tonsillar hypertrophy
Tonsillitis
Tooth extraction
Torticollis, spasmodic
Toxoplasmosis*
Tracheitis
Travel sickness
Trichinosis
Trigeminal neuralgia
Tuberculosis of the lungs*
Tumor albicans* (fungal ball)
Tumour albus
Typhoid fever*
U
Ulcerative colitis
Ulcers, corneal
Ulcers, crural
Ulcers, duodenal (PUD)
Ulcers, lower leg
Unrest, motor
Urethral stricture
Urethritis, non-specific*
Urinary tract infection, acute
Urinary tract infection, chronic
Urticaria
Uveitis
V
Vaginal atrophy
Vaginitis
Vagotonia
Varicella
Varicose veins
Verrucae (warts)
Vertigo
Vesicular eruptions (in general and on the conjunctiva)
Veterinary medicine
Viral diseases
Vitiligo
Vitreous body, opacity of
Vomiting
W
Warts
Whooping cough
Wounds
-
Biotherapeutic Index
Herba est ex luce
Plant life derives from light.Since the Biotherapeutic Index is not specific to individual countries, preparation names and formulas may vary slightly from country to country.
What is Homotoxicology?
Medicinal-therapeutical Mechanism of Action of…
Anti-homotoxic Preparations
Single Constituent Preparations and Classical Homeopathic Remedies
Catalysts
Suis Organ Preparations
Progressive Auto-Sanguis Therapy according to Reckeweg
Dosage of Heel Medications in Veterinary Medicine