Oroticum Acidum – Orotic Acid

The attenuations are prepared from Orotic acid, C₅H₄N₂O₄ · H₂O, MW: 174.1.

Orotic acid plays a part in important intermediate syntheses. It is produced from ureido-succinic acid (among other substances), by reaction with the intermediate stage: dihydro-orotic acid, and by subsequent DPN-dependent dihydrogenation. This reaction has been demonstrated in animal tissue and bacteria. As well as in milk, di- hydro-orotic acid is found in significant quantities in yeast extracts. Dihydro-orotic acid probably also plays a part in the synthesis of purine, as in the case of the syn- thesis of the pyramidine ring, which proceeds from α-ureido-succinic acid, (car- bamyl-aspartic acid). The latter is produced by a reaction of aspartic acid with car- bamyl phosphate, discovered by Lipmann. Thus earlier discoveries may be ex- plained, according to which the ureid carbon of citrullin can change to ureido-suc- cinic acid, orotic acid and the pyramidine bases of the nucleic acids. (Lowenstein and Cohen, according to Leuthardt.)

Dihydro-orotic acid reacts with 5-Phosphoribosyl-pyrophosphate, pyrophosphate being split off by the nucleotide-pyrophosphorylase, and conveyed to the oritidine, and oridine originates through the decarboxylisation of the latter. Thus Orotic Acid can be of use in impregnation phases, and also in liver damage.

A proving of this substance was conducted in the winter and spring of 1994, by Dr. David Riley. The results offer new information not present in the first edition of Dr. Reckeweg’s Materia medica which dealt primarily with the role of Orotic acid as an intermediate syntheses and its usefulness in treating liver disease.

Congruent symptoms with Dr. Reckeweg:

• abdominal pain and tenderness
• irritability

The most important symptoms from David Riley’s drug proving were:

Essential Characteristics

Increased energy and a general physical irritability are prominent symptoms of this remedy.

Feelings of contentment. Irritable and anxious. Sadness. Increased energy and in- creased physical irritability. Headaches. Coryza. Eruptions on the face. Pain in the mouth. Sore throat. Decreased appetite. Increased thirst. Flatulence. Abdominal pain. Diarrhea.

Mind

Anger. ANXIETY especially hypochondriacal. Aversions to company and aggrava- tion from the talk of others. Difficult concentration. CONTENTED FEELING, sense of well being, very cheerful, hopeful, and a sense of tranquillity. Delusions or visions of faces and ghosts or as if possessed. Despair about the future. DREAMS. Amorous dreams. Dreams of buildings or houses, airplanes, money, pleasant, water, or of mur- der. Tidy and fastidious. Forgetful of errands and spacy. Homesick. Hurried. Sense of independence. IRRITABLE. SADNESS especially in the afternoon. Sensitive. Persistent thoughts about household matters. Weeping and moody.

Generalities

Desire to be in open air in the outdoors. INCREASE IN ENERGY or improvement of energy levels especially in the afternoon, evening, or on waking. Faintness on exer- tion on bending over. Food desires of cold drinks, fruit, pickles, and vegetables. Ag- gravations from eating ice cream and rich food. Flushes of heat or chilliness. IN- CREASED PHYSICAL IRRITABILITY and hurriedness. Tense.

Vertigo

Vertigo while lying down or from sudden motion of the head. Dizziness.

Head

Sensation of lightness and floating at the crown as if it was not there. Numbness deep behind the nose in the brain like a novocain injection. HEADACHE. Dull pain in the left temple. Occipital headache in the evening. Head pain in the vertex.

Eye

Dryness. Burning and aching especially in the evening. Itchy inner canthi of the eyes.

Vision

Exertion of vision aggravates.

Ear

Itching in the ears improves and then reoccurs. Full sensation like a pressing in the ear after dinner.

Nose

Increased coryza or improvement of coryza. Thick greenish discharge especially post-nasal drip. Obstruction of the left nostril.

Face

Pale face. FACIAL ERUPTIONS. Eruptions of red spots on the cheeks that are dry and itching. Eruptions on the nose. Flushes of hot heat in the cheeks. Tingling sensation in the cheeks.

Mouth

Coated white tongue. PAIN in the mouth, gums, and tongue. Dryness of the mouth, particularly in the evening. Numbness in the mouth. Vesicles that are painful and burning.

Teeth Sensitive teeth. Throat

Dry sensation in the throat. Choking and constricted sensation in the throat. Scratchy pain. SORE THROAT PAIN worse on waking in the morning.

Stomach

APPETITE IS DECREASED or increased. Distension. Empty feeling in the stomach in the morning. Gurgling. NAUSEA. Cramping pain on waking in the morning. Rum- bling. THIRST.

Abdomen

FLATULENCE especially in the hypochondria and worse with distension after eating. ABDOMEN PAINS. Cramping pain better bending forward and curling up in bed in the morning. Drawing and tugging pain. Stitching pain better from deep breathing. Ten- sion of abdomen with rumbling at night.

Rectum

DIARRHEA in the morning on rising or in the afternoon. Flatus during diarrhea, at night, or better from releasing flatus.

Stools

Large or soft stools. Offensive stools. Yellow. Forcible stool.

Bladder

Increased need to urinate at night when in bed. Awareness of fullness in the blad- der.

Kidney

Aching pain in the kidney while riding in an automobile.

Urine

Bright yellow color. Genitalia, Male Excessive masturbation.

Genitalia, Female

Amenorrhea is interrupted. Brown menstrual bleeding. Menstrual bleeding is too frequent or of too short of duration. Painful menstrual cramps or improvement of pain. Scanty menses. Increased sexual desire.

Chest

Offensive perspiration in the axilla. Burning chest pain after dinner.

Back

Soreness and stiffness in the lumbar region improves. Stitching pain on motion ex- tends to the chest.

Extremities

Coldness of the hands and feet. Prickling heat in the upper thighs. Stiffness and tension in the lower limbs and joints of the lower limbs. Aching especially in the fin- gers and the upper and lower limbs.

Sleep

Difficulty in falling asleep. Sleepiness in the afternoon. Sleeplessness at night or

after waking during the night. Unrefreshing sleep. Frequent or early waking.