Nadidum – Nicotinamide Adenine Dinucleotide

The attenuations are prepared from nadide, disphosphopyridine nucleotide (DPN), NAD, C₂₁H₂₇N₇O₁₄P₂, MW: 663.4.

In particular the hydrogen-transferring enzymes of fermentation and of glycolysis, and of numerous other activities, contain dinucleotides as an active group; one of their bases is nicotinic acid amide, a derivative of pyridine. As they contain two or three phosphoric acid groups per molecule, they are also known as diphosphopyri- dine nucleotides (abbreviated to DPN) and triphosphopyridine nucleotides (TPN).

The most important function of Nadid is that of a reservoir for hydrogen, which is passed on in the respiratory chain by a logical arrangement of enzymes, on the basis of the redox-potential of the prosthetic groups. Hydrogen is passed on by the re- duced pyridine nucleotide to the flavoproteins, which for their part are reoxygenated by cytochrome, the hydrogen being ionised. In the valency-change of iron, only the electrons are transferred, the transfer to oxygen being carried out in the final stage by cytochrome oxidase.

The energy of oxidation which is released at each stage of the respiratory chain is captured as chemical energy and stored in the form of ATP (adenosine triphosphate), which is described as oxidative phosphorylation and takes place in the mitochondria of the cell. Thus it becomes clear that Nadid has important intermediate functions to fulfil, as a guarantor of these important conversions, particularly in cell respiration. Thus Nadid is indicated in impregnation and degeneration phases.

Nadid is also coupled with auxiliary active factors, and included in combination remedies for the activation or boosting of certain functions according to E. Bürgi’s theory.

The drug picture of Nadidum was composed in November 1993 by David Riley, M.D., Santa Fe (New Mexico), USA.

The most important symptoms from David Riley’s drug proving were:

Essential Characteristics

Sharp or stabbing pains are associated with this remedy in the ear, abdomen, and under the rib cage.

Difficult concentration. Memory weakness. Head pain. Tingling of the head. Stab- bing ear pain. Tingling in the lower jaw and chin. Painful sore throat. Nausea. Ab- dominal pain. Sharp pain in the ribs.

Mind

DIFFICULT CONCENTRATION. Delusions that everything is strange or has changed or seems unreal. Dreams that are bizarre, anxious, or amorous. Fear that something bad will happen will on vacation. Feeling indifferent. IRRITABILITY. Memory weakness especially for dates and places. Senses acute and especially sensitive to noise. Tran- quillity and peacefulness.

Generalities

Food desires of chocolate and alcohol. Worse in hot, humid weather.

Vertigo Dizziness. Head

Heat in the head. Sensation that the brain is loose in the head. Tingling of the head. HEAD PAIN that extends to the jaws or that is better while walking. Occiput pain. Temple pain especially left sided temple pain.

Ear

Left ear pain that is sharp or occurs with a headache.

Nose

Coryza (clear and not irritating) occurring throughout the day but worse in the evening.

Face

Numbness in the cheeks, jaws, or lips. Tingling in the chin or lower jaw.

Mouth

Small non-painful bumps all over the tongue, but worse on the left side.

Teeth Numbness. Throat

PAINFUL worse on the right side. Throat pain worse from swallowing.

Stomach

APPETITE is decreased or increased. NAUSEA or lack of expected nausea while on a boat in the ocean.

Abdomen

Flatulence that is painful trapped gas. ABDOMINAL PAIN that is stitching or from trapped gas.

Rectum

Constipation. Increased flatus.

Stools

Like hard balls. Hard or soft stool.

Genitalia, Female

Increased sexual desire. Vaginal itching.

Bladder

Decreased frequency of urination.

Chest

Bubbling sensation in the chest under the sternum at bedtime. CHEST PAIN. Pain worse on inspiration. Pain in the ribs during pre-menstrual syndrome or under the left pectoral muscle. Sore pain.

Back

Back stiffness.

Extremities

Cramps in the left thigh and groin. Swelling of the feet.

Sleep

Deep sleep in the afternoon. RESTLESS SLEEP. Sudden sleepiness.

Fever

Afternoon fever alternating with chills.