Category: Biotherapeutic Index

Drops _ Injection solution Composition:

Drops: 100 g cont.: Graphites D10, Graphites D30, Graphites D200, Calcium carbonicum Hahnemanni D10, Calcium carbonicum Hahnemanni D30, Calcium carbonicum Hahnemanni D200 0.5 g each. Contains 35vol.-% alcohol.

Injection solution: 1.1 ml cont.: Graphites D10, Graphites D30, Graphites D200, Calcium carbonicum Hahnemanni D10, Calcium carbonicum Hahnemanni D30, Calcium carbonicum Hahnemanni D200 5.5 µl each.

Indications:

Eczema, particularly dry, chronic; for long-term therapy in the case of scars and keloids.

Dosage:

Drops: In general, 10 drops 3 times daily. Long-term administration of the preparation (for several months) must be supervised by a therapist.

Injection solution: In general, 1 ampoule i.m., s.c., i.d., i.v., 1-3 times weekly.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Graphites (graphite)

Tendency towards adiposis, chronic (especially atonic) constipation; dry, cracked skin, but also eczema with honey-yellow crusts; eczema of the auditory meatus, chronic inflammation of the outer eye, chalazions.

Calcium carbonicum Hahnemanni (the inner white part of the oyster shell)

Pasty appearance, rickets, scrofulosis, exudative diathesis, sudation of the occiput; cold, moist feet; infantile facial eczema, petechial eruptions; wounds which will not heal, easily ulcerating.

Based on the individual homoeopathic constituents of Graphites-Homaccord, therapeutic possibilities result for its application as alternative constitutional remedy for exudative diathesis, adiposis and other deposition phases of the mesenchyma; it is also indicated for lipomas, atheromas, ganglions and especially for keloids. Experimentally for the long-term treatment of chronic-atonic constipation.

In skin diseases it is also recommended, if no action is observed quickly, to administer other Heel biotherapeutics in addition at intervals, such as Lamioflur, Psorinoheel and especially those with a certain reactive effect (Schwef-Heel, Sulfur-Heel), particularly for irritated, hypersensitive skin, intertrigo, dermatitis and eczema, as well as for neurodermatitis (in addition to Acidum fumaricum-Injeel and other acids of the citric acid cycle). For tinnitus aurium the combination with Barijodeel, Osteoheel S or also Cruroheel S, as well as with Suis-organ preparations (Os petrosum suis-Injeel and Funiculus umbilicalis suis-Injeel, etc.) is advantageous; experimentally for coxitis.

The dosage is adjusted according to the disease, the symptoms and the stage of the illness: 10 drops 3-4 times daily; in treatment continuing through months, at intervals  10 drops only once daily. 1 ampoule 1-3 times weekly i.m., s.c., i.v., possibly with other auxiliary remedies indicated.

INJECTION SOLUTION
Composition: 2.2 ml containing: Methylglyoxalum D10, Glyoxalum D10 22 mg each.

Indications:
Stimulation of the defensive mechanisms against toxins in blocked and defective enzymatic systems, disturbed glandular functions, degenerative diseases (cellular phases).

Dosage:
Standard dosage: Adults (and children 12 yrs. and older): 1 ampoule 1 to 3x weekly.
Glyoxal compositum injection solution may be administered by the s.c., i.d., i.m. or i.v. route.

Note:
If the patient briefly experiences temperature rise or local pain after administration, this should be interpreted as a positive response to therapy. These reactions should, however, be allowed to subside before repeated injection.

Package sizes:
Packs containing 10 and 100 ampoules of 2.2 ml each. (8521)

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Pharmacoclinical notes

Methylglyoxalum D10 (a glyoxyl with the addition of a methyl group):
A key reactive intermediate that is an α-oxoaldehyde (also termed an α-dicarbonyl) formed as an early glycation end product partly from the nonenzymatic reaction between reducing sugars and amine residues on proteins, lipids, and nucleic acids; can be formed from the spontaneous degradation of glucose during short periods of hyperglycemia, as can occur in impaired glucose tolerance; also can be formed from catabolism of ketone bodies and threonine, as well as from breakdown of triosephosphates; finally, can be formed from tobacco smoke and diet, especially with prolonged heating of food products. It is metabolized to D-lactate in a process that requires glutathione; unlike glyoxal, it also can be formed in an enzymatic process, such as from aldose reductase and glyoxalase reactions, and has 4 different pathways that can be involved in its detoxification.

It has well-established roles in the development of complications of diabetes; the development of advanced glycation end products (AGEs) is accelerated by hyperglycemia; these products accumulate in the sites, such as the retina, kidney, and atherosclerotic plaques, that are the most common sites for damage from diabetic complications.

Involved in the development of diabetic peripheral neuropathy, nephropathy, ocular disease, atherosclerotic disease, cardiomyopathy, and peripheral arterial disease; possibly provides the link between hyperglycemia and immune suppression; in particular, it is a potent suppressor of myeloid and T-cell immune function, such as the loss of interferon-a and interleukin 10.

AGEs also might activate monocytes to increase the expression of adhesion molecules and promote the production of cytokines and the proliferation of T cells. AGEs have been linked to the development of chronic diseases, such as the retinopathy, neuropathy, and nephropathy associated with long-term diabetes mellitus, macrovascular disease, Alzheimer disease, cataracts, and premature aging.

AGEs act through their receptor, which is termed receptor for AGEs (which is an immunoglobulin superfamily receptor) or via cross-links of the extracellular matrix to promote the oxidative stress and proinflammatory signaling components contributing to the neuronal and vascular complications of long-term diabetes. AGEs also directly cross-link type I collagen and elastin proteins of the vascular walls to increase vascular stiffness and resistance to proteolytic degradation and promote cardiovascular complications, as well as cross-link with myelin, tubulin, plasminogen activator, and fibrinogen to promote further intracellular and extracellular damage.

The composition of the extracellular matrix is modified by AGEs, with an increased expression of certain proteins, such as fibronectin, types III, IV, and VI collagen, and laminin, as well as through the upregulation of transforming growth factor-β and connective tissue growth factor; is cytotoxic to neuroglial cells.

Glyoxalum D10:
An α-oxoaldehyde formed as an early glycation end product from the product of the nonenzymatic glycosylation of proteins; can be formed from the spontaneous degradation of glucose during short periods of hyperglycemia, as can occur in impaired glucose tolerance; also can be formed in lipid peroxidation; is part of the AGE-receptor for AGE process previously described for methylglyoxalum.

Glyoxal and methylglyoxal are members of the carbonyl group series. According to Prof. W. F. Koch, they have the ability to depolymerize toxic material by acting as a hydrogen receptor. The same action is seen with the quinones. Glyoxal is one of the dangerous by-products of abnormal glucose metabolism in diabetics and is implicated in the formation of the so-called AGEs. These are immunogenic and stimulate an inflammatory response, which leads to tissue destruction. Glyoxal in a D10 may facilitate the excretion of this glyoxal and protect the tissues. Furthermore, through the carbonyl group, it acts as a hydrogen receptor, resulting in the formation of free radicals. Intracellular free radicals are especially dangerous to cancer cells, because they have poor antioxidant protection. Glyoxal was classically used infrequently, and only repeated when its action had worked. However, in modern homotoxicology, it is often used in a much more frequent manner because of the increase in intoxication and the dysregulation of modern patients.

References

1. Thornalley PJ, Langborg A, Minhas HS. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J. 1999;344(pt 1):109-116.
2. Cerami C, Founds H, Nicholl I, et al. Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A. 1997;94(25):13915-13920.
3. Vlassara H, Cai W, Crandall J, et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002;99(24):15596-15601.
4. Arribas-Lorenzo G, Morales FJ. Analysis, distribution, and dietary exposure of glyoxal and methylglyoxal in cookies and their relationship with other heat-induced contaminants. J Agric Food Chem. 2010;58(5):2966-2972.
5. Vander Jagt DL, Hunsaker LA. Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase. Chem Biol Interact. 2003;143-144:341-351.
6. Vander Jagt DL. Methylglyoxal, diabetes mellitus and diabetic complications. Drug Metab Drug Interact. 2008;23(1-2):93-124.
7. Goh SY, Cooper ME. Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab. 2008;93(4):1143-1152.
8. Price CL, Knight SC. Methylglyoxal: possible link between hyperglycaemia and immune suppression? Trends Endocrinol Metab. 2009;20(7):312-317.
9. Price CL, Hassi HO, English NR, Blakemore AI, Stagg AJ, Knight SC. Methylglyoxal modulates immune responses: relevance to diabetes. J Cell Mol Med. 2010;14(6B):1806-1815.
10. Ohashi K, Takahashi HK, Mori S, et al. Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction. Clin Immunol. 2010;134(3):345-353.
11. Negre-Salvayre A, Salvayre R, Augé N, Pamplona R, Portero-Otin M. Hyperglycemia and glycation in diabetic complications. Antioxid Redox Signal. 2009;11(12):3071-3109.
12. Zieman SJ, Melenovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005;25(5):932-943.
13. Vlassara H. Advanced glycation end-products and atherosclerosis. Ann Med. 1996;28(5):419-426.
14. Throckmorton DC, Brogden AP, Min B, Rasmussen H, Kashgarian M. PDGF and TGF-beta mediate collagen production by mesangial cells exposed to advanced glycosylation end products. Kidney Int. 1995;48(1):111-117.
15. Twigg SM, Cao Z, McCarthy DJ, et al. Renal connective tissue growth factor induction in experimental diabetes is prevented by aminoguanidine. Endocrinology. 2002;143(12):4907-4915.
16. Lee HK, Seo I, Suh DJ, Lee HJ, Park HT. A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells. J Neurochem. 2009;108(1):273-284.
17. Koch WF. The Survival Factor in Neoplastic and Viral Diseases. Publisher unknown; 1961.
18. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products: a review. Diabetologia. 2001;44(2):129-146.

Drops

Glonoin-Homaccord®

Injection solution Composition:

Drops: 100 g cont.: Glonoinum D3, Glonoinum D10, Glonoinum D30, Lycopus virginicus D1, Lycopus virginicus D4, Lycopus virginicus D10, Lycopus virginicus D30 0.1g each; Crataegus Ø 60 g. Contains 45 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Glonoinum D4, Glonoinum D10, Glonoinum D30, Lycopus virginicus D2, Lycopus virginicus D4, Lycopus virginicus D10, Lycopus virginicus D30 1.1 µl each; Crataegus D4 8.8 µl. Indications:

Tachycardia, particularly with excessive secretion of the thyroid gland; anginous disorders.

Dosage:

Drops: In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, over a period lasting up to two hours. Long-term application of the  preparation (over several months or longer) must be supervised by a therapist.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Glonoinum (nitroglycerol)

Palpitations extending to the neck, a sense of impending death, anginal disorders. Lycopus virginicus (gypsy-wort)

Hyperthyroidism with tachycardia and nervous coronary disorders. Crataegus (whitethorn)

Pre-insufficiency, coronary insufficiency, senile heart, focal-toxic/infectious myocardial weakness, general sedative.

Based on the individual homoeopathic constituents of Glonoin-Homaccord, therapeutic possibilities result for the treatment of tachycardia, particularly of hyperthyroidism, anginal disorders with radiating pain (in the arm, breast, abdomen and neck). In these cases Glonoin-Homaccord acts, in addition to Cralonin, Cardiacum-Heel (as massive initial-dose therapy for disorders) and Aurumheel N drops (for signs of slight decompensation), not only symptomatically but also, with long administration, to provide a lasting cure. Glonoin-Homaccord can also be used harmlessly for a fairly long time. In glaucoma as auxiliary remedy, in plethora and polycythaemia in addition to Nux vomica-Homaccord and possibly Melilotus-Homaccord. The dosage is adjusted according to the disease, the symptoms and the stage of the illness: in acute disorders 5-10 drops every 10-15 minutes until improvement, possibly alternating with the above- mentioned preparations. For long-term therapy, 10 drops 3 times daily. 1 ampoule i.v. for an attack in sporadic disorders, otherwise 1 ampoule i.m., s.c., i.v. 1-3 times  weekly, possibly with Cralonin, Angio-Injeel, Tabacum-Injeel, Aconitum-Injeel S, Carbo vegetabilis-Injeel, is rapidly effective, possibly also after myocardial infarction, together with Traumeel S, Carbo compositum, Strophanthus compositum, etc.

Drops Composition:

Drops: 100 g cont.: Ginseng Ø 20 g; Acidum sarcolacticum D2, Hydrastis canadensis D10, Conium maculatum D10, Psorinum-Nosode D28, Colchicum autumnale D10,

Pulsatilla pratensis D10, Kreosotum D10, Viscum album D8, Sulfur D10, China D10, Galium aparine D8, Sempervivum tectorum D8, Coenzymum A D10, Natrium diethyloxalaceticum D8, Adenosinum triphosphoricum D10, Nadidum D10 1g each. Contains 35 vol.-% alcohol.

Indications:

Improvement of the constitution in intoxication of the defensive system, also in neoplasias.

Dosage:

In general, 10 drops 3-6 times daily.

Package sizes:

Drop bottles containing 30 and 100 ml.

Pharmacological and clinical notes

Ginseng (ginseng root)

Conditions of exhaustion of all kinds. Acidum sarcolacticum (sarcolactic acid)

Acid-base regulation in the connective tissues. Hydrastis canadensis (golden seal)

Remedy for affections of the mucosa: thick, viscid, ropy, yellowish-white secretions from all mucous membranes; improves tonicity in cachectic and marasmic conditions. Conium maculatum (spotted hemlock)

Glandular swelling, as in scrofulous and cancerous conditions, vertigo, remedy for senile conditions.

Psorinum-Nosode (psorinum-nosode)

Lack of reaction, debility, chronic rheumatism, chronic exanthema. Colchicum autumnale (meadow saffron)

Gastroenteritis, rheumatism of the muscles and joints, peri- and endocarditis, adjuvant in neoplasm phases.

Pulsatilla pratensis (wind flower)

Migrating disorders, vertigo, neuralgic pains, venous stasis. Kreosotum (beech tar creosote)

Mucosal catarrh with acrid secretions, e.g. in bronchitis, leucorrhoea, dental caries, eczema of the hands.

Viscum album (mistletoe)

Sudden attacks of vertigo, headache, especially in the forehead, constitutional hypertonia, precancerous state and neoplasia.

Sulfur (sulphur)

Reagent in all chronic diseases, cellular activity is influenced catalytically. China (Peruvian bark)

Remedy for debility, burning and weakness between the shoulder blades, anaemia, sensitivity to cold.

Galium aparine (goosegrass)

Precancerous state, diuretic, oedema, favours granulation of ulcers. Sempervivum tectorum (houseleek)

Herpes zoster, haemorrhoids, nephritis, precancerous state. Coenzymum A (coenzyme A)

Coenzyme for transacetylation.

Natrium diethyloxalaceticum (sodium oxalacetate)

Active factor of the citric acid cycle and of redox systems; weakness of the defensive system.

Adenosinum triphosphoricum (adenosine triphosphate) Support of the energy-consuming system.

Nadidum (nicotinamide adenine dinucleotide)

Biocatalyst, stimulation of the end oxidation in the respiratory chain.

Intoxication of all kinds must be broken down by the main defensive system (according to H. H. Reckeweg). In degenerative diseases, including, in particular, cancer, most

serious endogenous toxin levels are present, which cannot be overcome without medical aid.

In such cases Ginseng compositum is indicated, Ginseng, according to experience, acting to strengthen the anterior lobe of hypophysis-cortex of the suprarenal gland system, and Acidum sarcolacticum which, in degenerative phases and particularly in neoplasia, always acts against pronounced acidosis of the affected tissue in the reversal effect.

Sulphur, Psorinum and Pulsatilla possess far-reaching constitutional action in the form of loosening and eliminating toxins, while Hydrastis canadensis, Conium maculatum, Colchicum autumnale, Kreosotum, Viscum album, as well as Galium aparine and Sempervivum tectorum act against the tendency towards the formation of neoplasia, when especially the medium potencies have a far-reaching action, without provoking unwanted or excessive reactions. The enzyme systems, always strained or also damaged in the cellular phases, are stimulated by the intermediary catalysts Natrium diethyloxalaceticum, Coenzyme A, Adenosine triphosphate and Nadidum in the similarity principle, resulting in favourable overall effects in various degenerative phases, including, in particular, neoplasia. In addition, injections of appropriate Composita-Heel (Coenzyme compositum, Ubichinon compositum, Hepar compositum, Mucosa compositum), also Galium-Heel, advantageously mixed with Aqua Daun D2 and cAMP D8, and in particular Engystol N and Pulsatilla compositum are indicated; Thalamus compositum (against faulty neural control). In the case of colitis (following X- ray/radium therapy), in addition to Veratrum-Homaccord and possibly Nux vomica- Homaccord, Podophyllum compositum (liquid and ampoules) is also indicated; in Precancerous state and for pronounced neoplasia, stimulation therapy with Viscum compositum (medium, forte); also for powerful stimulation of the defensive mechanism, Echinacea compositum forte S.

Ginseng compositum is an auxiliary therapeutical agent not only in neoplasia, leukaemia, Hodgkin’s disease (lymphogranulomatosis), but also in preliminary stages and upon suspicion of precancerous states, when there is strain of (the cortex of) the suprarenal gland (deep rings around the eyes, and conditions of exhaustion), as well as for excessive toxin levels of any kind (auxiliary remedy for burns).

As alternating remedy to Ginseng compositum, Galium-Heel is especially suitable, among other medicaments. For intestinal disorders of any kind: Nux vomica- Homaccord. In addition, Molybdän compositum should always be administered orally as trace element donor-regulator.

Drops _ Injection solution Composition:

Drops: 100 g cont.: Gelsemium sempervirens D2, Gelsemium sempervirens D10, Gelsemium sempervirens D30, Gelsemium sempervirens D200 0.4 g each; Rhus toxicodendron D3, Rhus toxicodendron D10, Rhus toxicodendron D30, Rhus toxicodendron D200, Cimicifuga racemosa D2, Cimicifuga racemosa D10, Cimicifuga racemosa D30, Cimicifuga racemosa D200 0.3 g each. Contains 35 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Gelsemium sempervirens D4, Gelsemium  sempervirens D10, Gelsemium sempervirens D30, Gelsemium sempervirens D200 4.4 µl each; Rhus toxicodendron D5, Rhus toxicodendron D10, Rhus toxicodendron D30, Rhus toxicodendron D200, Cimicifuga racemosa D4, Cimicifuga racemosa D10, Cimicifuga racemosa D30, Cimicifuga racemosa D200 3.3 µl each.

Indications:

Cervical syndrome, cervical migraine (osteochondrosis of the cervical region of the vertebral column), neuralgia in various positions.

Contraindications:

Hypersensitivity to the genus Rhus of the Anacardiaceae family.

Side effects:

None known.

Interactions with other medication:

None known.

Dosage:

Drops: In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, over a period lasting up to two hours. Long-term application of the  preparation (over several months or longer) must be supervised by a therapist.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Gelsemium sempervirens (wild jasmine)

Neuralgia, migraine, headache, numbness, vertigo, cardiac pangs. Rhus toxicodendron (poison oak)

Rheumatism and neuralgia worsening in cold, wet weather, after being exposed to rain or when at rest, e.g. neuralgia of the arm, intercostal neuralgia. sciatic neuralgia, pain in the limbs.

Cimicifuga racemosa (black cohosh)

Neuralgia, cervical syndrome, sudden, shooting pains and rapid change of symptoms, pain extending from the back or neck over the head, osteochondrosis, especially of the dorsal and cervical regions of the vertebral column, sciatic neuralgia.

Based on the individual homoeopathic constituents of Gelsemium-Homaccord, therapeutic possibilities result for the treatment of cervical migraine (in addition to Spigelon and Osteoheel S, Cimicifuga-Homaccord, etc.); osteochondrosis of the cervical vertebrae (Colocynthis-Homaccord, China-Homaccord S); sensitivity to changes in the weather, occipital neuralgia.

Also typical migraines (shock-therapy alternation with Spigelon). Neuralgia of the head, in the cervical syndrome, may result from chronic nerve pressure in the foramina transversalia, due to faulty deportment, therefore posture correction must be followed unconditionally. For symptomatic headache, e.g. influenza, angina and other feverish illnesses, as well as during or before menses, Gelsemium-Homaccord (possibly alternating with Spigelon) is indicated. It is also often effective in agoraphobia (fear of open spaces) in addition to Anacardium-Homaccord, Nervoheel, Valerianaheel etc., as well as for dysmenorrhoea (Spascupreel, Hormeel S, Gynäcoheel, etc.).

The dosage is adjusted according to the disease, the symptoms and the stage of the illness: 10 drops 3-4 times daily; in sporadic diseases when an attack occurs, 10 drops every 15 minutes, alternating with other preparations. 1 ampoule daily in acute disorders, otherwise 1 ampoule 1-3 times weekly i.m., s.c., i.v., forming wheals in the area of the pain, possibly mixed with Spascupreel, Colocynthis-Homaccord, Neuralgo- Rheum-Injeel, Cimicifuga-Homaccord, etc.

Tablets Composition:

1   tablet cont.: Argentum nitricum D6, Arsenicum album D6 30 mg each; Pulsatilla pratensis D4, Nux vomica D4, Carbo vegetabilis D6, Antimonium crudum D6 60 mg each.

Indications:

Acute and chronic gastritis, heartburn, meteorism.

Dosage:

In general, 1 tablet to be dissolved under the tongue 3 times daily. In acute disorders initially 1 tablet every 15 minutes, over a period lasting up to two hours.

Package sizes:

Packs containing 50 and 250 tablets.

Pharmacological and clinical notes

Argentum nitricum (silver nitrate)

Meteorism, gastrocardiac syndrome, gastritis, ventricular ulcers, gastrorrhagia. Arsenicum album (white arsenic)

Burning gastralgia, unquenchable thirst, gastritis, diarrhoea. Pulsatilla pratensis (wind flower)

Remedy for affections of the mucous membranes in the mucodermal reaction phases, dyspepsia, meteorism.

Nux vomica (vomit-nut)

Gastro-intestinal and hepatic remedy, spasms, consequences of misuse of stimulants (alcohol, nicotine).

Carbo vegetabilis (wood charcoal)

Dyspepsia, flatulence, pyrosis, conditions of collapse, acts as toxin adsorbent. Antimonium crudum (black antimony)

Gastralgia, sensation of fullness, intolerance of alcohol, circulatory failure.

Based on the individual constituents of Gastricumeel, therapeutic possibilities result for the treatment of gastritis acuta and chronica, with and without hyperacidity; pyrosis, meteorism and gastrocardiac syndrome.

Gastricumeel is indicated as basic therapeutic agent in every stage of gastritis. Frequently needed additional remedies: Spascupreel (spasms), Cardiacum-Heel (anginal disorders), Duodenoheel (duodenal ulcers), Erigotheel (duodenal ulcers), Veratrum-Homaccord (gastroenteritis), Hepeel (implication of the liver), Chelidonium- Homaccord (cholangitis), Nux vomica-Homaccord (spasmodic constipation), Diarrheel S (dyspepsia, meteorism).

The dosage is adjusted according to the disease, the symptoms and the stage of the illness: 1 tablet dissolved on the tongue 3(-4) times daily. For acute disorders, massive initial-dose therapy: 1 tablet every 10-15 minutes with the appropriate additional remedies.

Drops _ Injection solution Composition:

Drops: 100 g cont.: Galium aparine D3, Galium mollugo D3 4 g each; Sedum acre D3, Sempervivum tectorum D4, Clematis recta D4, Thuja occidentalis D3, Caltha palustris D3, Ononis spinosa D4, Juniperus communis D4, Hedera helix D4, Betula alba D2, Saponaria officinalis D4, Echinacea angustifolia D5, Calcium fluoratum D8, Phosphorus D8, Aurum metallicum D10, Argentum metallicum D8, Apis mellifica D12, Acidum nitricum D6, Pyrogenium-Nosode D6 5 g each; Urtica urens D3 2 g. Contains 35 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Galium aparine D3, Galium mollugo D3 0.44 µl each; Sedum acre D3, Sempervivum tectorum D4, Clematis recta D4, Thuja occidentalis D3, Caltha palustris D3, Ononis spinosa D4, Juniperus communis D4, Hedera helix D4, Betula alba D2, Saponaria officinalis D4, Echinacea angustifolia D5, Calcium fluoratum D8, Phosphorus D8, Aurum metallicum D10, Argentum metallicum D8, Apis mellifica D12, Acidum nitricum D6, Pyrogenium-Nosode D6 0.55 µl each; Urtica urens D3 0.22 µl.

Indications:

To activate the non-specific defensive mechanism, particularly in chronic diseases. Dosage:

Drops: In general 10 drops 3 times daily.

Injection solution: Initially daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d.,  i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Galium aparine (goosegrass)

Precancerous state, diuretic, oedema, favours granulation of ulcers. Galium mollugo (lady’s bedstraw)

Detoxicating agent. Sedum acre (stonecrop)

Precancerous state, haemorrhoidal disorders, fissura ani. Sempervivum tectorum (houseleek)

Precancerous state, herpes zoster, haemorrhoids, nephritis. Clematis recta (clematis)

Hyperplastic, hard glandular swelling, urethral stricture, prostatitis; vesicular, highly irritating eczema.

Thuja occidentalis (Arbor vitae)

Constitutional remedy, especially for diseases with a tendency towards proliferative processes.

Caltha palustris (marsh marigold)

Uterine carcinoma, bronchitis, pemphigus. Ononis spinosa (spinous rest-harrow) Nephrosis, nasal haemorrhage.

Juniperus communis (juniper) Diuretic, glomerulonephritis. Hedera helix (ivy)

Acute and chronic nasal (sinus) catarrh. Betula alba (birch)

Diuretic, choleretic remedy, mucosal catarrh and, in particular, also gastritis. Saponaria officinalis (soapwort)

Eczema, diuretic, cholagogue, acute chills. Echinacea angustifolia (narrow-leaved cone flower)

To strengthen the defensive mechanism, inflammation of every kind and location, septic processes.

Calcium fluoratum (calcium fluoride) Glandular swellings (of stony hardness). Phosphorus (phosphorus)

Remedy for affections of the parenchyma (lungs, heart, liver, kidneys), decalcification of bone.

Aurum metallicum (gold)

Far-reaching remedy for affections of the tissues, arteriosclerosis, depression (tendency towards suicide).

Argentum metallicum (silver)

Deficiency of memory, vertigo, angiospasms, coxitis. Apis mellifica (honey bee)

Oedema, exerts a channelling action on the connective tissues. Acidum nitricum (nitric acid)

Dyscrasia, eczema, dermatosis, chronic nephritis. Pyrogenium-Nosode (pyrogenium nosode) Infectious reaction phases, oedema.

Urtica urens (small nettle)

Rheumatism, gout, eczema, dermatosis.

Based on the individual homoeopathic constituents of Galium-Heel, therapeutical possibilities result for the activation of the unspecified defenses, particularly in chronic diseases and especially in all phases with enzyme damage on the right of the  biological division (impregnation, degeneration and neoplasm phases), regardless of whether internal (asthma, bronchiectasis, hypertonia, hepatic disorders, achylia gastrica, colitis), neurological (Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, causalgia, trigeminal and other types of neuralgia), urological, dermatological, opthalmological, ears, nose and throat (otosclerosis, papillomas, anosmia) or other manifestations of cellular processes are involved. Precancerous state and therapeutical damage represent a primary indication for Galium-Heel.

Galium-Heel acts inductively on detoxicating intracellular enzyme systems; further, through the stimulation of the main defensive system, thereby promoting detoxicating and secretory reactions and leading, in particular, to a strengthening of the function of the connective tissues.

Galium-Heel, by cleansing the homotoxic terrain, can delay neoplasm phases  or render them stationary. Galium-Heel is, at the same time, a geriatric medicament.

The dosage is adjusted according to the disease, the clinical picture and the stage of the illness. In continuous treatment, including in geriatrics, 10 drops 3 times daily. At the start, massive initial-dose therapy for 1-2 days, 10 drops every 15-30 minutes until phase conversions are achieved. In precancerous state and neoplasm phases (especially for sarcoma), increasing and decreasing dosage of 5-50 drops (daily 3-5 drops more or less), 3-4 times daily. Avoid excessive reactions! Daily maximum dose (DMD): 150-200 drops.

Galium-Heel ampoules at first daily, later once to 3 times weekly i.m., s.c.. i.v.

For (pre-)cancerous state, simultaneous antihomotoxic stimulation with Engystol N and Traumeel S and promotion of detoxication with Hepeel, Psorinoheel and Lymphomyosot, also with intermediate catalysts of the citric acid cycle, suis-organ preparations, etc.

Injection solution Composition:

Injection solution: 1.1 ml cont.: Origanum vulgare D6, Origanum vulgare D10, Origanum vulgare D30 6.6 µl each; Erythraea centaurium D10, Erythraea centaurium D30 4.4 µl each.

Indications:

Ulcus ventriculi et duodeni.

Dosage:

In acute disorders 1 ampoule daily, otherwise 3-1 times weekly i.m., s.c., i.d., i.v. Package sizes:

Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Origanum vulgare (marjoram)

Gastro-intestinal catarrh (with or without ulceration), antispasmodic. Erythraea centaurium (centaury)

Gastric, hepatic and biliary disorders, antipyretic.

Based on the individual homoeopathic constituents of Erigotheel, therapeutical possibilities result for the treatment of ventricular and duodenal ulcers, hyperacidity, parapyloric syndrome according to Strauss = irritation triad: hyperaesthesis, supersecretion and hypermotility of the stomach.

As the bitter principles contained in both components of the preparation are able to increase the excitability of the sympathetic nervous system, the effect of Erigotheel is essentially conditioned by the indirect alleviation of the vagotonia caused by the stimulation of the antagonistic sympathetic nervous system. In addition to a mild spasmolysis, Erigotheel leads to a biological regulation of the secretory function of the gastroduodenal mucosa, creating the necessary physiological conditions for curing an ulcer, which are also of great significance in preventing recurrent ulcers. Also chronic ulcers and the dumping syndrome can be favourably influenced therapeutically by Erigotheel.

The dosage is adjusted according to the disease, the clinical picture and the stage of the illness: Erigotheel is advantageously administered over a fairly long period, during which 3 injections (i.m., s.c., i.v.) are given weekly in the form of segmental therapy, in

the skin of the right side of the epigastrium, or paravertebrally. In acute disorders or as initial treatment, daily injections for several days.

Combination with Traumeel S in an i.v. or i.m. mixed injection enhances the therapeutical success.

For particularly therapy-resistant cases it is recommended, in addition to an Erigotheel- Traumeel S mixed injection to be administered every 2 days i.v. or i.m., on the intervening days to administer 1 ampoule of Erigotheel in the hyperesthetic zones in the form of wheals or injected s.c.

The additional oral therapeutic agent is Duodenoheel (1 tablet 3 times daily); in chronic cases Anacardium-Homaccord; where there is a suspicion of precancerous state, Galium-Heel, etc.

Drops _ Injection solution Composition:

Drops: 100 g cont.: Ferrum metallicum D8, Ferrum metallicum D30, Ferrum metallicum D200, Ferrum phosphoricum D8, Ferrum phosphoricum D30, Ferrum phosphoricum D200 0.2g each; Ferrum sulfuricum D6, Ferrum sulfuricum D10, Ferrum sulfuricum D30, Ferrum sulfuricum D200 0.1g each; Ferrum sesquichlorum solutum D4, Ferrum sesquichlorum solutum D10, Ferrum sesquichlorum solutum D30, Ferrum sesquichlorum solutum D200 0.05 g each; Spiraea ulmaria D2, Spiraea ulmaria D10, Spiraea ulmaria D30, Spiraea ulmaria D200 0.45 g each. Contains 35 vol.-% alcohol.

Injection solution: 1.1 ml cont.: Ferrum metallicum D10, Ferrum metallicum D30, Ferrum metallicum D200, Ferrum phosphoricum D10, Ferrum phosphoricum D30, Ferrum phosphoricum D200 2.2 µl each; Ferrum sulfuricum D8, Ferrum sulfuricum D10, Ferrum sulfuricum D30, Ferrum sulfuricum D200 1.1 µl each; Ferrum sesquichlorum solutum D6, Ferrum sesquichlorum solutum D10, Ferrum sesquichlorum solutum D30, Ferrum sesquichlorum solutum D200 0.55 µl each; Spiraea ulmaria D4, Spiraea ulmaria D10, Spiraea ulmaria D30, Spiraea ulmaria D200 4.95 µl each.

Indications:

Shoulder and arm syndrome, epicondylitis.

Dosage:

Drops: In general 10 drops 3 times daily. In acute disorders initially 10 drops every 15 minutes, over a period lasting up to two hours. Long-term application of the  preparation (over several months or longer) must be supervised by a therapist.

Injection solution: In acute disorders 1 ampoule daily, otherwise 3-1 times weekly i.m., s.c., i.d., i.v.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 1.1 ml.

Pharmacological and clinical notes

Ferrum metallicum (iron)

Rheumatism, shoulder and arm syndrome, secondary anaemia. Ferrum phosphoricum (iron phosphate)

Feverish and inflammatory conditions, shoulder and arm syndrome. Ferrum sulfuricum (iron sulphate)

A longing for warmth, condition worsening in cold conditions, muscular rheumatism, hyperaemia.

Ferrum sesquichlorum solutum (iron chloride) Anaemia, iron deficiency diseases.

Spiraea ulmaria (meadowsweet)

Epicondylitis, rheumatism of the muscles and joints.

Based on the individual homoeopathic constituents of Ferrum-Homaccord, therapeutic possibilities result for the treatment of arthritis and rheumatism, particularly in the region of the shoulder joints and the arms. Cervical syndrome with radiation into the arms, bursitis calcarea, periarthritis humeroscapularis, epicondylitis (in addition to Traumeel S ointment), secondary anaemia and anaemic headache, anaemia with nephritis; for pernicious anaemia as auxiliary remedy (Galium-Heel, Graphites- Homaccord, Lamioflur, Engystol N, Traumeel S, etc.)

Drops _ Injection solution

Euphorbium compositum- Nasal Spray S Composition:

Drops: 100 g cont.: Euphorbium D3, Pulsatilla pratensis D2, Luffa operculata D6, Mercurius bijodatus D8, Mucosa nasalis suis D8, Hepar sulfuris D10, Argentum nitricum D10, Sinusitis-Nosode D13 1g each. Contains 45 vol.-% alcohol.

Injection solution: 2.2 ml cont.: Euphorbium D4, Pulsatilla pratensis D2, Luffa operculata D6, Mercurius bijodatus D8, Mucosa nasalis suis D8, Hepar sulfuris D10, Argentum nitricum D10, Sinusitis-Nosode D13 22 µl each.

Nasal spray: 100 g cont.: Euphorbium D4, Pulsatilla pratensis D2, Luffa operculata D2, Mercurius bijodatus D8, Mucosa nasalis suis D8, Hepar sulfuris D10, Argentum nitricum D10, Sinusitis-Nosode D13 1g each. Benzalkonium chloride 0.01%.

Indications:

Drops, Injection solution: Chronic sinusitis (maxillary sinus, frontal sinus, ethmoidal sinus, sphenoid sinus), catarrh of the ear passages, dropsy of the middle ear.

Nasal spray: Rhinitis of varied origins (viral, bacterial, allergic); rhinitis sicca, rhinitis hyperplastica and atrophicans, for the auxiliary treatment of ozena; chronic sinusitis; to facilitate nasal respiration in hay fever.

Contraindications:

Drops, Injection solution: The preparation includes an iodine-containing ingredient. In cases of thyroid disorder with reduced iodine tolerance use only on the advice of a physician.

Nasal-Spray: Hypersensitivity to benzalkonium chloride.

Side effects:

Drops, Injection solution: In rare cases, increased flow of saliva may occur after taking this medication. If this happens, the therapist should be consulted.

Interactions with other medication:

None known.

Dosage:

Drops: In general, 10 drops 3 times daily. In acute disorders, initially 10 drops every 15 minutes, followed by a reduction to 10 drops 6 times daily.

Injection solution: In acute disorders daily, otherwise 3-1 times weekly 1 ampoule i.m., s.c., i.d., or if necessary, i.v.

Nasal spray: Spray 1-2 shots into each nostril 3-5 times daily; for children under 6 years, 1 shot 3-4 times daily. The product can also be used safely for infants.

Package sizes:

Drops: Drop bottles containing 30 and 100 ml.

Injection solution: Packs containing 5, 10, 50 and 100 ampoules of 2.2 ml. Nasal spray: Atomiser without propellant, 20 ml.

Pharmacological and clinical notes

Euphorbium (euphorbium)

Mucosal catarrh of the upper part of the respiratory tract, e.g. rhinitis and sinusitis, catarrh of the ear passages.

Pulsatilla pratensis (wind flower)

Migrating disorders, remedy for affections of the mucosa, thick, mild and greenish yellow discharges; conjunctivitis, rhinitis.

Luffa operculata (vegetable sponge)

Allergic and vasomotory rhinitis, rhinitis atrophicans, sinusitis, hay fever. Mercurius bijodatus (mercury(ll) iodide)

Angina, particularly viral, acute nasal catarrh, catarrh of the sinuses, suppurations. Mucosa nasalis suis (nasal and sinus mucosa)

Sinusitis chronica, polysinusitis, ozena, nasal polypi, affections of the sinuses. Hepar sulfuris (calcium sulphide)

Tendency towards suppurations, particularly on the skin and lymph glands, tonsillar abscesses.

Argentum nitricum (silver nitrate)

Pharyngitis, laryngitis, hoarseness, conjunctivitis, headache. Sinusitis-nosode (sinusitis-nosode)

Acute and chronic suppurations of the sinuses, lymphatism, ozena, hay fever.

Based on the individual homoeopathic constituents of Euphorbium compositum, therapeutical possibilities result with drops and injection solution for the treatment of acute and chronic sinusitis (maxillary, frontal, ethmoidal, sphenoidal), as well as of tubal catarrh (ear) and of dropsy of the middle ear. Nasal spray (dosing spray) for chronic dry nasal catarrh, dry nasal mucosa in chronic sinusitis; to facilitate nasal respiration in nervous and allergic coryza (hay fever); for acute nasal catarrh and catarrh caused by a chill (dissolves the secretions, ensures free nasal respiration and relieves frontal pressure); as auxiliary remedy for atrophic rhinitis (ozena).

The preparation, which is available as drops to be taken as well as in the form of injection solution, has shown excellent effects in an extensive series of tests,  especially for chronic sinusitis, and particularly the dry form (atrophy of the nasal mucous membrane), bringing about reactivation and, in the form of regressive vicariation, restoring the lubrication of the mucosa. Occasionally it is beneficial, at the same time to administer also the preparation Mucosa compositum, after a fairly long use of caustics, after ointments which reduce mucus, etc., also the preparations which act effectively on the enzymes, Coenzyme compositum, Ubichinon compositum; for inflammatory symptoms also Echinacea compositum S (possibly forte i.v.) or Traumeel S and Engystol N.

Also for aphonia, Euphorbium compositum injection solution has proved effective in combination with Echinacea compositum S, Mucosa compositum and Ubichinon compositum.

For dropsy of the middle ear and for chronic otitis, all 3 forms of medicament should be administered simultaneously.

Euphorbium compositum-Ñasal Spray S stimulates the mucosal functions, their action being directed especially towards the nose and paranasal sinuses, having a regulatory effect on the widest variety of diseases of the mucosa of the sinuses, including acute and allergic coryza. Avoiding the otherwise usual deturgescence of the mucosa, and without reactive hyperaemia with the consequent constriction of the respiratory tract, the nasal mucous membrane alone is cleansed from crusts and secretions by the solvent (physiological salt solution). Irksome desiccation is avoided, free respiration ensured and the unpleasant frontal pressure dispelled. In addition, the administration  of Euphorbium compositum-Nasal Spray S over a fairly long period does not bring about a decrease in their action, but on the contrary, this is increased with time.