Hepeel®

Written by

Urenus

in

Compositions

Tablets
1 tablet containing: Lycopodium clavatum D3, Chelidonium majus D6, Cinchona pubescens D3, Myristica fragrans D4 30 mg each; Silybum marianum D2, Phosphorus D6 15 mg each; Veratrum album D6 60 mg; Citrullus colocynthis D6 90 mg.

Injection solution
1.1 ml containing: Lycopodium clavatum D2, Chelidonium majus D6, China D2, Myristica fragrans D3 1.1 mg each; Silybum marianum D1, Phosphorus D5 0.55 mg each; Veratrum album D5 2.2 mg; Citrullus colocynthis D5 3.3 mg.

Indications

Primary and secondary functional disorders of the liver; damaged liver.

Contraindications

Because of the constituent Celandine (Chelidonium) do not use during pregnancy and lactation. Do not use in case of hypersensitivity to Carduus marianus or other plants of the daisy family (Asteraceae) or in case of hypersensitivity to quinine.

Side effects

In rare cases, reactions of hypersensitivity, such as skin allergy or fever, may occur after exposure to drugs that contain quinine. In such cases, you must see a doctor.

Note

A quinine or quinidine sensitization may occur.

Interactions with other medication

None known.

Dosage

Tablets
Standard dosage: Adults (and children 12 yrs and older): 1 tablet to be dissolved in the mouth 3× daily.

Injection solution
Standard dosage: Adults (and children 12 yrs and older): 1 ampoule 1 to 3× weekly. Hepeel injection solution may be administered by the s.c., i.d., i.m. or i.v. route.
Acute or initial dosage: Adults (and children 12 yrs and older): 1 ampoule daily, and then continue with standard dosage.

Package sizes

Tablets: Packs containing 50 and 250 tablets. (47787)
Injection solution: Packs containing 10 and 100 ampoules of 1.1 ml each. (46791)

Pharmacological notes

  • Lycopodium clavatum: liver cirrhosis,1-8 cholecystitis,9 hepatitis,2-6,10-15 dermatoses,1,10,12,14,16-19 dermatitis,6,20 jaundice,2,14,19,21-25 abdominal distention,5,22,25-27 gastritis,1,5,6,14,21,25-28 eczema,1,10,12,14,16,17,19,23,25,28,29 and acne,6,7,10,19,25,27
  • Chelidonium majus: liver cirrhosis,5,14,27,30,31 jaundice,1,10-12,15-22 abdominal distention,14,17,27,31 and gastritis,5,21,27,28
  • Cinchona pubescens: gastritis,5-6,9,13,25 loss of appetite,4,11,12,14,16,25,28,31,37,38 liver cirrhosis,5-7,30-31 hepatitis,5,13,25,27,30,33 and cholecystitis,5,23
  • Myristica fragrans: liver cirrhosis and loss of appetite,4-7,11,12,14,16,21,25,27,33,34,40,41
  • Silybum marianum: liver cirrhosis,4-6,15-17,21,26,34 hepatitis,5-7,32,37 cholecystitis,6 and loss of appetite,4,6,9,16,26,30
  • Phosphorus: liver cirrhosis,2-7,10-14,19,26,27,38,42 gastritis,5,11-14,18,22,36,43 hepatitis,4,10,12-14,19,25,26,40,44 and abdominal distention,7,16,18,22,25,27
  • Veratrum album: abdominal distention,6,14-16,25-28,45,46 liver cirrhosis, hepatitis, loss of appetite,1,5,7,14,16,25,46 acne,6,7,14,27,30 and eczema
  • Citrullus colocynthis: abdominal distention,6,7,14,16,25,38,41,46-48 loss of appetite,5,14,16,25,27 and jaundice,8,20

Clinical notes

Because of the individual constituents of Hepeel, the medication can be offered for the following conditions:

  1. Liver disorders: liver cirrhosis, hepatitis, and jaundice.
  2. Other intestinal disorders: gastritis, abdominal bloating, gastrocardiac syndrome, cholangitis, and cholecystitis.
  3. Loss of appetite.
  4. Adjunctive therapy in chronic diseases, such as dermatoses, eczema, and acne vulgaris.

Note: Hepeel was recently examined for its in vitro effect on HepG2 hepatoblastoma cells. It has significant antioxidative, antiproliferative, and biochemical effects that point toward a hepatoprotective and tumerostatic action. Hepeel can be used in disorders such as cirrhosis, which has a potentially malignant outcome; the previously described evidence suggests the mechanism of its protective action.

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