p-Aminobenzoesaeureäthylester-Injeel
D 12, D 30, D 200 0.367 ml each.
p-Aminoethyl benzoate (benzocaine, anesthesine) is a skin and, in particular, a mucous membrane anesthetic which also has antiseptic properties. This precursor of the local anesthetic procaine (p-amino-2′-diethylaminobenzoate) can, by resorptive means via the skin (benzocaine in the corresponding ointments), or via the mucosa (benzocaine in analgesic lozenges or dragees for painful oral and pharangeal infections, or in the treatment of gastritis with or without ulcer, involving the administration of liquid remedies, after which the patient is required to change position frequently), give rise to intoxication (formation of methaemoglobin).
The Contra-Indications of local anesthetics in systemic and parenteral application are serious transfusion disorders and acute cardiac insufficiency. At higher dosages they may lead to bradycardia and disturbances of the rhythm of myocardial activity; possibly also to stupor and cramp. Also vertigo and emesis are among the side effects of local anesthetics, In addition, it should be pointed out that benzocaine can also cause eczematous drug rashes, and in surface anesthesia, when a certain total dosage is exceeded, benzocaine can cause cerebral intoxication with disturbances of consciousness, aphnea or also signs of central nervous irritation, such as impairment of hearing, equilibrium and sight, as well as emesis and cramp; sometimes also intoxication of the myocardium (leading to acute, sometimes fatal, circulatory failure). Group sensitization to the para-amino group in benzocaine, procaine, tetracaine, antifebrin, PAS and sulphonamides exist.
Indications
Therapeutic or retoxic damage as discussed above.
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