Sulfonamid-Injeel
D 12, D 30, D 200 0.367 ml each.
Sulfonamid-Injeel forte
D 6, D 12, D 30, D 200 0.275 ml each.
The sulphonamides can be described as enzyme poisons which concurrently inhibit enzyme systems in which para-aminobenzoic acid is active as coenzyme (e.g. growth factor H of yeast in Streptobact. plant.). The bacteriostatic properties of the sulphonamides are achieved, therefore, through their action as enzyme poisons, which leads, and must lead, to very many side effects, e.g. gastro-intestinal disorders, cholestasis, leucothrombopenia and possibly agranulocytosis. Sulphonamide fever can, on the one hand, be caused allergically but can also indicate serious toxic damage, such as hepatitis or haemolytic anemia. Contra-Indications for the administration of sulphonamides are: the last weeks of pregnancy, the period of lactation and the first weeks of life of the infant: danger of formation of sulphaemoglobin or methaemoglobin, as in the infant, physiologically, the methaemogiobin reductatse is not yet fully capable of functioning. In the Met-Hb-formation, a toxic metabolic product formed in the liver microsomes, p-hydroylaminobenzene sulphonamide, participates decisively. Further, this may lead to a pronounced sulphonamide allergy, indeed, in the form of sulphonamide fever (see above), but also in the form of renal and hepatic disorders (see above) and allergic skin reactions. Erythema exudativum multiforme (including in the case history) represents a contraindication for sulphonamide therapy.
Indications
The clinical pictures indicated above, especially when these arise after treatment with sulphonamides, which may have been given a considerable time previously.