Zeel® P

Injection solution

Zeel®

Tablets

Zeel® T

Ointment Composition:

Zeel P Injection solution: 2.2 ml cont.: Extractum (1:10) cartilaginissuis, Extractum (1:10) funiculiumbilicalis suis, Extractum (1:10) embryonissuis, Extractum (1:10) placentaesuis 22 ng each; Rhus toxicodendron Ø, Arnica montana Ø 0.22 mg each; Solanum dulcamara Ø, Symphytum officinale Ø 22 µg each; Sanguinaria canadensis  Ø 33 µg; Sulfur Ø (=D4) 39.6 µg; Nadidum, Coenzyme A, Acidum alpha-liponicum, Natrium diethyloxalaceticum 0.22 ng each.

Zeel Tablets: 1 tablet cont.: Extractum (1:10) cartilaginis suis, Extractum (1:10) funiculiumbilicalis suis, Extractum (1:10) embryonissuis, Extractum (1:10) placentaesuis 0.3 µg each; Rhus toxicodendron Ø 0.108 mg, Extr. flor. Arnicae (spir. fld. 1:1) 0.06 mg; Solanum dulcamara Ø 3 µg; Symphytum officinale Ø 0.03 µg; Sanguinaria canadensis Ø 4.5 µg; Sulfur Ø 5.4 µg; Acidum silicicum colloidale 3 ng; Nadidum, Coenzyme A, Acidum alpha-liponicum, Natrium diethyloxalaceticum 0.03 ng each.

Zeel T Ointment: 100 g cont.: Cartilago suis D2, Funiculus umbilicalis suis D2, Embryo suis D2, Placenta suis D2 0.001g each; Rhus toxicodendron D2 0.270 g; Arnica montana D2 0.300 g; Solanum dulcamara D2 0.075 g; Symphytum officinale D8 0.750

g; Sanguinaria canadensis D2 0.225 g; Sulfur D6 0.270 g; Nadidum D6, Coenzymum  A D6, Acidum alpha-liponicum D6, Natrium diethyloxalaceticum D6 0.010 g each; Acidum silicicum D6 1.000 g.

Ointment base: Hydrophilic ointment (DAB 10) cont.: Emulsifying cetylstearyl alcohol, ethanol, purified water, liquid paraffin, soft white paraffin, preserved with 12.9 vol.-% ethanol.

Indications:

Arthrosis (in particular gonarthrosis); polyarthrosis, spondylarthrosis, scapulohumeral periarthritis.

Contraindications:

Zeel P Injection solution: Hypersensitivity to botanicals of the Compositae family or the genus Rhus of the Anacardiaceae family.

Zeel T Ointment: Hypersensitivity to arnica, the genus Rhus of the Anacardiaceae family and constituents of the ointment base.

Zeel Tablets: Hypersensitivity to the genus Rhus of the Anacardiaceae family. Allergy to arnica.

Side effects:

Zeel T Ointment: In rare cases, allergic skin reactions may occur. Interactions with other medication:

None known.

Dosage:

Zeel P Injection solution: In general twice weekly 1 ampoule i.m., s.c., i.d., i.v., intraarticularly, periarticularly, or if necessary, paravertebrally. In the case of large joints, 2 ampoules on each occasion.

Warning: In rare cases after intra-articular administration of Zeel (P) (injection  solution), temporary painful joint irritation may occur, possibly with sterile effusions. Administration of anti-inflammatory medication is appropriate palliative treatment in such cases.

Zeel Tablets: In general, 1 tablet to be dissolved under the tongue 3 times daily.

Zeel T Ointment: Apply to the affected areas, rubbing in gently in the morning and evening, or if necessary more often, possibly applying an ointment dressing.

Package sizes:

Tablets: Packs containing 50 and 250 tablets.

Injection solution: Packs containing 10, 50 and 100 ampoules of 2.2 ml. Ointment: Tubes containing 50 and 100 g of ointment.

Pharmacological and clinical notes

Cartilago suis (cartilage)

Arthrosis deformans, coxitis, periarthritis humeroscapularis. Funiculus umbilicalis suis (Wharton’s jelly [umbilical cord]) Damage to connective tissues, circulatory disorders.

Embryo suis (embryo)

For revitalization in the cellular phases. Placenta suis (placenta)

Circulatory disturbances, pernios. Rhus toxicodendron (poison oak)

Rheumatism and neuralgia, worse in cold, wet weather; polyarthritis, diseases of the mucosa and connective tissues.

Arnica montana (mountain arnica)

To stimulate the healing of wounds, rheumatism, injuries arising from falls, blows or contusions; pains in the back and limbs.

Solanum dulcamara (bittersweet)

Remedy to counteract the effects of wet weather, sensation of having caught a chill, rheumatic disorders.

Symphytum officinale (comfrey)

Injuries to the tendons, ligaments and periosteum; acts on the joints in general, neuralgia of the knee.

Sanguinaria canadensis (blood-root)

Neuralgic and rheumatoid pains of the joints and muscles. Sulfur (sulphur)

Reagent in all chronic diseases; cellular activity is influenced catalytically. Silicea (sillicic acid)

Weakness and impairment of the connective tissues; weakness of the ligaments. Nadidum (nicotinamide adenine dinucleotide)

Coenzyme, stimulation of the end oxidation in the respiratory chain. Coenzyme A (coenzyme A)

Coenzyme for transacetylation. Acidum alpha-liponicum (thiotic acid)

Coenzyme in the decomposition of pyruvic acid. Natrium diethyloxalaceticum (sodium oxalacetate)

Active factor of the citric acid cycle and of redox systems; sensitivity to damp and wind. For the maintenance of normal articular functions, undisturbed co-ordination of the metabolism of the synovial membrane and synovial fluid on the one hand and of the arthrodial cartilage on the other, is indispensable. In the cartilage, according to the Embden-Meyerhof model, lactic acid or lactate is formed, which reaches the outer cellular layer of the joint capsule through the synovial fluid. There, by stimulation of the end oxidation through the citric acid cycle, the necessary energy is released. In arthrosis, there is a pathological alteration of the metabolism of the connective tissue  in the joint (cartilage, synovial membrane and also synovial fluid), characterized by increased degradation of the connective tissue structures. This results, therefore, in disproportion between catabolic and anabolic-metabolic processes. The task of effective therapy is to normalize the disturbed metabolism, as well as offering components for possible incorporation.

The decisive energy-liberating reaction of the metabolism is the formation of hydrogen, which is then transferred, to a great extent, to nicotinamide adenine dinucleotide (nadidum); thus, for example, the whole of the hydrogen liberated in the course of the citric acid cycle is transferred to nadidum, the starting member of the respiratory chain. Precisely the oxidoreduction, catalysed by nadidum, between lactic acid and pyruvic acid, or the reverse, is of decisive importance in the metabolism of the joints.

Thioctic acid is also a hydrogen-transferring co-factor which, above all, participates decisively in the oxidative decarboxylation (conversion of pyruvic acid to “activated acetic acid“).

In the interaction with Coenzyme A, the formation of the “activated acetic acid” is made possible which, for its part, represents the

“initiator” of the citric acid cycle, while oxalacetate can be described as the fuel, or also as the engine, of the citric acid cycle.

The treatment of rheumatic diseases with sulphur has long been known. It is only through the biochemical research into mucopolysaccharide sulphates, however, that it was confirmed, i.e. could be established, that the organism can incorporate or convert the sulphur into chondroitin sulphates intrinsic to the body.

The organ constituents provide important components of the connective tissue (cartilage, funiculus umbilicalis), while placenta pro-

motes the circulation and the embryo has an additional stimulating action.

The botanical constituents from Rhus toxicodendron, Solanum dulcamara, Sanguinaria canadensis, Symphytum and Arnica montana are applied for rheumatic diseases of the joints, etc., including when the disorders are worsened in wet weather.

The medicaments blended into a pharmacologically active and non-toxic combination in Zeel, on the basis of many years’ medical experience and the most recent

biochemical research form a highly valuable remedy for chronic diseases of the joints, as can be seen from the composition and from what has been confirmed by clinical  and practical tests.

Based on the individual homoeopathic constituents of Zeel, therapeutic possibilities result for the treatment of arthrosis (in particular gonarthrosis), polyarthrosis, spondylarthrosis, periarthritis humeroscapularis.

The dosage is adjusted according to the disease, the clinical picture and the stage of the illness: 1 tablet to be dissolved on the tongue 3-5 times daily. 1 ampoule or, for the big joints, 2 ampoules on each occasion, s.c., i.d., i.v., or periarticularly, possibly paravertebrally. The ointment should be applied or rubbed in morning and evening  and, if necessary, more often, at the affected areas, possibly using an ointment dressing.